Chronic maternal feed restriction impairs growth but increases adiposity of the fetal guinea pig
Chronic maternal feed restriction impairs growth but increases adiposity of the fetal guinea pig
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DOI：
10.1152/ajpregu.00360.2004
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发表时间：
2005-01-01
影响因子：
2.8
通讯作者：
Owens, JA
中科院分区：
文献类型：
--
作者：
Kind, KL;Roberts, CT;Owens, JA
出生时身材矮小与成年后中心性肥胖的风险增加和瘦体重减少有关。本研究调查了豚鼠产前诱发肥胖的发病时间，这发生在母体限饲后，豚鼠是一种与人类一样在出生前形成大量脂肪组织储存的物种。我们研究了母体限饲[从妊娠前4周至妊娠中期70%自由采食，然后90%至妊娠第60天（期限类似于69天）]对豚鼠胎儿生长和身体组成的影响。母体限饲降低了妊娠60天时的胎仔（-39%）和胎盘（-30%）重量，并降低了肝脏、二头肌、脾脏和胸腺重量（相对于胎仔重量），而脑、肺、肩胛间和腹膜后脂肪垫的相对重量增加。在肩胛间贮库中，母体饲料限制降低了多房脂肪的体积密度，增加了单房脂肪的体积密度，导致肩胛间单房脂肪的相对重量增加。母体限饲并没有改变肾周脂肪的相对重量或贮库内脂肪细胞群的体积密度，但增加了单室脂质室的大小。豚鼠母体限饲与主要器官（包括肝脏和骨骼肌）重量降低相关，但与胎儿肥胖增加相关，单房脂肪组织相对较少。如果这种早发性肥胖持续存在，它可能会导致代谢和心血管功能障碍，这些后代的喂养限制的母亲发展为成年人。
Small size at birth has been associated with an increased risk of central obesity and reduced lean body mass in adult life. This study investigated the time of onset of prenatally induced obesity, which occurs after maternal feed restriction, in the guinea pig, a species that, like the human, develops substantial adipose tissue stores before birth. We examined the effect of maternal feed restriction [70% ad libitum intake from 4 wk before to midpregnancy, then 90% until day 60 gestation ( term similar to 69 days)] on fetal growth and body composition in the guinea pig. Maternal feed restriction reduced fetal ( - 39%) and placental ( - 30%) weight at 60 days gestation and reduced liver, biceps muscle, spleen, and thymus weights, relative to fetal weight, while relative weights of brain, lungs, and interscapular and retroperitoneal fat pads were increased. In the interscapular depot, maternal feed restriction decreased the volume density of multilocular fat and increased that of unilocular fat, resulting in an increased relative weight of interscapular unilocular fat. Maternal feed restriction did not alter the relative weight of perirenal fat or the volume density of adipocyte populations within the depot but increased unilocular lipid locule size. Maternal feed restriction in the guinea pig is associated with decreased weight of major organs, including liver and skeletal muscle, but increased adiposity of the fetus, with relative sparing of unilocular adipose tissue. If this early-onset obesity persists, it may contribute to the metabolic and cardiovascular dysfunction that these offspring of feed-restricted mothers develop as adults.