Oxidative stress regulation by DJ-1 in the retinal pigment epithelium.

Oxidative stress regulation by DJ-1 in the retinal pigment epithelium.
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DOI:
10.1007/978-1-4614-3209-8_81
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发表时间:
2014
影响因子:
--
通讯作者:
Cai H
Cai H
中科院分区:
医学4区
文献类型:
--
作者:
Bonilha VL;Rayborn ME;Yang X;Xie C;Cai H

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DJ-1是一种在包括大脑在内的许多组织中表达的蛋白质,由于其与帕金森病(PD)的相关性,它已被广泛研究。据报道,DJ-1具有抗氧化剂、氧化还原敏感性分子伴侣和转录调节剂的功能,其通过修饰调节细胞存活的信号通路来保护细胞免受氧化应激。在这里,我们讨论了我们的进展对DJ-1功能的表征在保护RPE氧化应激。
DJ-1 is a protein expressed in many tissues including the brain where it has been extensively studied due to its association with Parkinson’s Disease (PD). DJ-1 was reported to function as an antioxidant, redox-sensitive molecular chaperone, and transcription regulator, which protected cells from oxidative stress by modifying signaling pathways that regulate cell survival. Here we discuss our progress toward characterization of the DJ-1 function in the protection of RPE to oxidative stress.
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