DIRECTING CELL-DIVISION DURING DEVELOPMENT
DIRECTING CELL-DIVISION DURING DEVELOPMENT
复制标题
DOI：
10.1126/science.2683080
复制
发表时间：
1989-11-03
期刊：
影响因子：
56.9
通讯作者：
LEHNER, CF
中科院分区：
文献类型：
--
作者：
OFARRELL, PH;EDGAR, BA;LEHNER, CF
Several evolutionarily conserved proteins constitute a universal mitotic trigger that is precisely controlled during the orderly cell divisions of embryogenesis. As development progresses, the mechanisms controlling this trigger change. Early divisions are executed by maternally synthesized gene products, and inXenopusthey are timed by the accumulation and periodic degradation of cyclin, a trigger component. Later, the zygotic genome assumes control, and inDrosophila, zygotic transcription is required for production of another trigger protein, the product ofstring. After this transition to zygotic control, pulses ofstringtranscription define the timing of highly patterned embryonic cell divisions and cyclin accumulation is not rate limiting.
