Common polymorphisms in the USF1 gene are not associated with type 2 diabetes in French Caucasians.
Common polymorphisms in the USF1 gene are not associated with type 2 diabetes in French Caucasians.
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DOI：
10.2337/diabetes.54.10.3040
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发表时间：
2005-10
期刊：
影响因子：
7.7
通讯作者：
F. Gibson;S. Hercberg;P. Froguel
中科院分区：
文献类型：
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作者：
F. Gibson;S. Hercberg;P. Froguel
上游转录因子 1 (USF1) 是基本螺旋-环-螺旋亮氨酸拉链家族中普遍表达的转录因子，已被证明可以调节涉及葡萄糖和脂质代谢的大量关键基因的表达。 USF1 基因位于染色体 1q22-q23，位于人类基因组中复制最一致的 2 型糖尿病易感基因座内。在这项研究中，我们研究了八种常见的 USF1 单核苷酸多态性 (SNP) 对法国白种人群体 2 型糖尿病易感性的影响。 USF1 SNP 基因分型，包括先前与家族性混合性高脂血症相关的两个 SNP（rs2073658 和 rs3737787），均未显示与 2 型糖尿病相关的证据。此外，USF1 SNP 与血糖正常受试者的血浆葡萄糖、甘油三酯、总胆固醇或载脂蛋白 A1 或 B 水平无关。总共鉴定了四种常见的 USF1 单倍型，占染色体的 99% 以上。病例和对照受试者的USF1单倍型分布没有显着差异。总之，我们在此报告，我们无法找到任何证据来支持 USF1 基因的遗传变异对法国白种人群体 2 型糖尿病易感性产生重大影响的假设。
Upstream transcription factor 1 (USF1) is a ubiquitously expressed transcription factor of the basic helix-loop-helix leucine zipper family that has been shown to regulate the expression of a raft of key genes involved in glucose and lipid metabolism. The USF1 gene is located at chromosome 1q22-q23, within the most consistently replicated type 2 diabetes susceptibility locus in the human genome. In this study, we have examined the contribution of eight common USF1 single nucleotide polymorphisms (SNPs) to type 2 diabetes susceptibility in the French Caucasian population. None of the USF1 SNPs genotyped, including two SNPs previously associated with familial combined hyperlipidemia (rs2073658 and rs3737787), showed evidence of association with type 2 diabetes. In addition, USF1 SNPs were not associated with plasma levels of glucose, triglycerides, total cholesterol, or apolipoproteins A1 or B in normoglycemic subjects. A total of four common USF1 haplotypes were identified, accounting for >99% of chromosomes. There was no significant difference in the USF1 haplotype distribution of the case and control subjects. In conclusion, we report here that we were unable to find any evidence to support the hypothesis that genetic variation in the USF1 gene makes a significant contribution to type 2 diabetes susceptibility in the French Caucasian population.