International Journal of General Medicine Dovepress Importance of Innate Mucosal Immunity and the Promises It Holds
International Journal of General Medicine Dovepress Importance of Innate Mucosal Immunity and the Promises It Holds
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通讯作者：
A. Dwivedy;P. Aich
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作者：
A. Dwivedy;P. Aich
身体防御机制已经进化，可以保护动物免受病原微生物和癌症的侵袭。它能够产生多种细胞和分子，能够特异性识别和消灭无数种外来入侵者。这些细胞和分子在动态网络中共同作用，被称为免疫系统。先天性粘膜免疫由多种识别受体分子组成，包括Toll样受体、NOD样受体和RIG-I样受体。这些识别受体分子有效地识别各种入侵的病原体，并产生免疫反应以阻止它们的进入并中和它们的不良后果，例如组织损伤。此外，它们还能调节严重感染时的适应性反应，并有助于产生记忆反应。大多数感染是通过粘膜发生的。了解粘膜表面的初始宿主防御反应或先天免疫对于控制这些感染和保护系统非常重要。本综述的目的是讨论各种先天粘膜制剂的作用和功能及其在理解生理免疫反应中的重要性，以及它们在开发新干预措施中的作用。
The body defense mechanism has evolved to protect animals from invading pathogenic microorganisms and cancer. It is able to generate a diverse variety of cells and molecules capable of specifically recognizing and eliminating a limitless variety of foreign invaders. These cells and molecules act together in a dynamic network and are known as the immune system. Innate mucosal immunity consists of various recognition receptor molecules, including toll-like receptors, NOD-like receptors, and RIG-I-like receptors. These recognition receptor molecules recognize various invading pathogens effectively, and generate an immune response to stop their entry and neutralize their adverse consequences, such as tissue damage. Furthermore, they regulate the adaptive response in cases of severe infection and also help generate a memory response. Most infections occur through the mucosa. It is important to understand the initial host defense response or innate immunity at the mucosal surface to control these infections and protect the system. The aim of this review is to discuss the effects and functions of various innate mucosal agents and their importance in understanding the physiological immune response, as well as their roles in developing new interventions.