Cepharanthine inhibited HIV-1 cell-cell transmission and cell-free infection via modification of cell membrane fluidity
Cepharanthine inhibited HIV-1 cell-cell transmission and cell-free infection via modification of cell membrane fluidity
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DOI：
10.1016/j.bmcl.2014.03.041
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发表时间：
2014-05-01
影响因子：
2.7
通讯作者：
Okada, Seiji
中科院分区：
文献类型：
--
作者：
Matsuda, Kouki;Hattori, Shinichiro;Okada, Seiji
评价了千金藤碱(CEP)的抗HIV-1活性。CEP稳定质膜流动性，抑制HIV-1感染细胞的HIV-1包膜依赖的细胞间融合以及无细胞感染。提示CEP通过降低质膜流动性来抑制HIV-1的进入过程，因此质膜是预防病毒感染的相同靶点。(C)2014爱思唯尔有限公司。保留所有权利。
The anti-HIV-1 activity of cepharanthine (CEP), a natural product derived from Stephania cepharantha Hayata, was evaluated. CEP stabilized plasma membrane fluidity and inhibited HIV-1 envelope-dependent cell-to-cell fusion of HIV-1-infected cells as well as cell-free infection. It is suggested that CEP inhibited the HIV-1 entry process by reducing plasma membrane fluidity, and the plasma membrane is therefore an identical target to prevent viral infection. (C) 2014 Elsevier Ltd. All rights reserved.