Principles governing recruitment of motoneurons during swimming in zebrafish
Principles governing recruitment of motoneurons during swimming in zebrafish
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DOI：
10.1038/nn.2704
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发表时间：
2011-01-01
影响因子：
25
通讯作者：
El Manira, Abdeljabbar
中科院分区：
文献类型：
--
作者：
Gabriel, Jens Peter;Ausborn, Jessica;El Manira, Abdeljabbar
运动运动是由神经元网络协调的，神经元网络产生连续的肌肉激活。不同的运动神经元需要有序地调动，以产生适当的速度和力量的运动。但是，有关征聘命令的机制尚未得到充分澄清。利用体外幼/成年斑马鱼脑干-脊髓制备，我们发现运动神经元被组织成具有特定地形位置的四个池，并被逐渐招募以不同频率产生游泳。招募的阈值不是由运动神经元的输入阻力决定的，而是由特定的生物物理特性和突触电流的强度共同决定的。我们的研究结果为运动过程中控制运动神经元招募的细胞和突触计算提供了见解。
Locomotor movements are coordinated by a network of neurons that produces sequential muscle activation. Different motoneurons need to be recruited in an orderly manner to generate movement with appropriate speed and force. However, the mechanisms governing recruitment order have not been fully clarified. Using an in vitro juvenile/adult zebrafish brainstem-spinal cord preparation, we found that motoneurons were organized into four pools with specific topographic locations and were incrementally recruited to produce swimming at different frequencies. The threshold of recruitment was not dictated by the input resistance of motoneurons, but was instead set by a combination of specific biophysical properties and the strength of the synaptic currents. Our results provide insights into the cellular and synaptic computations governing recruitment of motoneurons during locomotion.