Retinal vessel diameter in normal and glaucomatous eyes: the Beijing eye study
Retinal vessel diameter in normal and glaucomatous eyes: the Beijing eye study
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DOI：
10.1111/j.1442-9071.2007.01627.x
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发表时间：
2007-12-01
影响因子：
4
通讯作者：
Jonas, Jost B.
中科院分区：
文献类型：
--
作者：
Wang, Shuang;Xu, Liang;Jonas, Jost B.
目的：评价中国成人伴青光眼和不伴青光眼视网膜血管直径。方法：以人群为基础的横断面研究纳入了5324名受试者中的4439名（应答率83.4%），所有受试者年龄均在40岁及以上。本研究分为农村部分（1973例，44.4%）和城市部分（2466例，55.6%）。对2418名受试者的彩色视盘和眼底照片进行形态计量学检查。在视盘边缘和距视盘边缘2mm处测量视网膜血管直径。主要观察指标为视网膜血管直径。结果：视网膜动脉直径在颞下区最宽（P < 0.001），其次是颞上区（P < 0.001），鼻上区（P < 0.001），最后是鼻下区。除了鼻下静脉，视网膜静脉也是如此。四根主干直径的排列顺序与年龄、性别或远视与近视无关。随着年龄的增长，动脉直径呈下降趋势，而静脉直径在所有年龄组均呈下降趋势。青光眼视神经损伤的眼动脉明显变薄（P < 0.001），而视网膜静脉直径差异无统计学意义。结论：颞下拱廊的视网膜小动脉和静脉直径最大，其次是颞上拱廊、鼻上拱廊和鼻下拱廊。青光眼患者视网膜动脉直径减小，视网膜静脉直径随年龄增大而减小。
Purpose: To assess retinal vessel diameter in adult Chinese with and without glaucoma.Methods: The population-based, cross-sectional study included 4439 of the 5324 subjects asked to participate (response rate 83.4%), all aged 40 years or older. This study was divided into a rural part (1973 subjects [44.4%]) and an urban part (2466 subjects [55.6%]). Colour optic disc and fundus photographs were morphometrically examined for 2418 subjects. The retinal vessel diameters were measured at the optic disc border and at a distance of 2 mm to the optic disc border. The main outcome measure was the retinal vessel diameter.Results: Diameters of the retinal arteries were significantly (P < 0.001) the widest in the temporal inferior region, followed by the temporal superior region (P < 0.001), the nasal superior region (P < 0.001) and finally the nasal inferior region. Except for the nasal inferior vein, the same held true for the retinal veins. The sequence of the main four vessel trunks with respect to their diameters was not associated with age, gender or hyperopia versus myopia. The artery diameters showed a tendency to decrease in older age, while the vein diameters decreased across all age groups. Eyes with glaucomatous optic nerve damage showed significantly (P < 0.001) thinner arteries while the retinal vein diameters were not different.Conclusions: Diameters of the retinal arterioles and veins are the widest in the temporal inferior arcade, followed by the temporal superior arcade, the nasal superior arcade and finally the nasal inferior arcade. Retinal artery diameters decrease with glaucoma, and retinal vein diameters decrease with age.