Zinc Deficiency Causes to Decrease Plasma Calcium and Ionized Calcium Concentrations Prior to an Increase in the Plasma Parathyroid Hormone Concentration in Rats
Zinc Deficiency Causes to Decrease Plasma Calcium and Ionized Calcium Concentrations Prior to an Increase in the Plasma Parathyroid Hormone Concentration in Rats
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缺锌会导致大鼠血浆钙和离子钙浓度降低，然后血浆甲状旁腺激素浓度增加
DOI：
10.11344/nano.8.67
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Yokoyama A.
中科院分区：
文献类型：
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作者：
Kaga N;Akasaka T;Horiuchi R;Yoshida Y; Yokoyama A.
本文观察了缺锌对大鼠血浆钙和离子钙浓度的影响。本实验将4周龄雄性SD大鼠分为缺锌组（Zn-Def）、低锌组（Low-Zn）和对照组（配对喂养），连续28天监测大鼠血浆钙、钙离子（Ca ~（2+））、甲状旁腺激素（PTH）和镁离子（Mg ~（2+））浓度。与Pair组大鼠相比，Zn-Def组大鼠在喂养4、14、21、28 d后血浆Ca ~（2+）浓度显著降低。三组间血浆Mg ~（2+）浓度无明显变化。与配对喂养大鼠相比，Zn-Def大鼠的血浆PTH浓度在喂养21天后趋于升高，并且在喂养28天后显著升高。结果表明，缺锌导致血浆钙和Ca 2+浓度下降之前，血浆PTH浓度的增加。
The effects of zinc deficiency on plasma calcium and ionized calcium concentrations were examined in rats. We monitored plasma concentrations of calcium, ionized calcium (Ca2+), parathyroid hormone (PTH) and ionized magnesium (Mg2+) in male 4 week-old Sprague-Dawley rats, that were divided into three groups: zinc-deficient (Zn-Def), low-zinc (Low-Zn), and control pair-fed to Zn-Def (Pair-fed) groups, for 28 days. Comparing to Pair-fed rats, plasma calcium and Ca2+ concentrations of Zn-Def rats were found to be significantly lower after 4, 14, 21, 28 days of feeding. There was no significant change of the plasma Mg2+ concentration among three groups. Comparing to Pair-fed rats, the plasma PTH concentration in Zn-Def rats tended to be higher after 21 days of feeding, and significantly higher after 28 days of feeding. The results suggest that zinc deficiency causes to decrease plasma calcium and Ca2+ concentrations prior to an increase of the plasma PTH concentration.