Glucose transport in chronically altered rat nephrons.
Glucose transport in chronically altered rat nephrons.
复制标题
慢性改变的大鼠肾单位中的葡萄糖转运。
DOI：
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发表时间：
1982
影响因子：
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通讯作者：
W. Lorentz
中科院分区：
文献类型：
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作者：
R. Kramp;W. Lorentz
在麻醉大鼠上进行微量注射实验，研究正常肾小管和慢性病变肾小管对葡萄糖的吸收能力。慢性肾小管病变是指急性损伤后维持解剖修复和代偿性改变的肾小管。当正常或改变的近曲早期或晚期注射的葡萄糖负荷小于或等于1.5或小于或等于10pmol时，TG是完整的。S-1号。在正常肾小管中，TMG分别为10pmo1和5pmol.分别于早期和晚期近端微量注射S-1。早期近端微量注射改变的小管后，发现不同水平的TMG。它们与补偿性增长的程度有关。TMG约为12、24或35 pmol。S-1在改变的小管中分别有少量、中度或主要的补偿性生长。晚期近端微量注射后，TMG为15pmol。S以1比1获胜。病变肾小管的甘油三酯变异性大于正常肾小管。由此证明了结构和功能代偿性变化之间的相关性。此外，还发现近端直小管对葡萄糖的一种重要的、尽管是潜在的吸收能力。
Microinjection experiments were performed in anesthetized rats to study the tubular absorptive capacity for glucose (TG) in normal and chronically altered tubules, i.e., tubules that sustained anatomical repair and compensatory changes of their previously normal configuration after acute damage. TG was complete when the glucose load injected in normal or altered early or late proximal convolutions was less than or equal to 1.5 or less than or equal to 10 pmol . s-1, respectively. In normal tubules, TmG was 10 and 5 pmol . s-1 after early and late proximal microinjections, respectively. After early proximal microinjections in altered tubules, different levels of TmG were found. They related to the degree of compensatory growth. TmG was approximately 12, 24, or 35 pmol . s-1, respectively, in altered tubules with minor, moderate, or major compensatory growth. After late proximal microinjections, TmG was 15 pmol . s-1. TG variability was greater in altered than in normal tubules. Correlation between structural and functional compensatory changes was thus demonstrated. Furthermore, an important, albeit latent, absorptive capacity for glucose of the proximal straight tubule was found.