Coffee consumption and coronary heart disease in men and women - A prospective cohort study
Coffee consumption and coronary heart disease in men and women - A prospective cohort study
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DOI：
10.1161/circulationaha.105.598664
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发表时间：
2006-05-02
期刊：
影响因子：
37.8
通讯作者：
Hu, FB
中科院分区：
文献类型：
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作者：
Lopez-Garcia, E;van Dam, RM;Hu, FB
背景-我们研究了长期习惯性喝咖啡与冠心病（CHD）风险之间的关系。方法和结果-我们对44005名男性和84488名女性进行了一项前瞻性队列研究，这些男性和女性没有心血管疾病或癌症史。1986年首次对男性和1980年对女性的咖啡消费量进行了评估，然后每2至4年重复一次;随访持续到2000年。我们记录了2173例男性冠心病（1449例非致命性心肌梗死和724例致命性冠心病）和2254例女性冠心病（1561例非致命性心肌梗死和693例致命性冠心病）。在男性中，在调整年龄、吸烟和其他CHD风险因素后，不同类别累积咖啡消耗量的CHD相对风险（RR）（< 1杯/月、1杯/月至4杯/周、5至7杯/周、2至3杯/天、4至5杯/天和≥ 6杯/天）分别为1.0、1.04（95%置信区间0.91 - 1.17），1.02（0.91至1.15），0.97（0.86至1.11）、1.07（0.88至1.31）和0.72（0.49至1.07;趋势P = 0.41）;在女性中，RR分别为1.0、0.97（0.83至1.14）、1.02（0.90至1.17）、0.84（0.74至0.97）、0.99（0.83至1.17）和0.87（0.68至1.11;趋势P = 0.08）。按吸烟状况、饮酒、2型糖尿病史和体重指数分层，结果相似。同样，当我们检查最近的咖啡消费量时，我们没有发现任何影响。咖啡因摄入量五分位数的RR从0.97（0.84至1.10）从第二个五分位数降至0.97（0.84至1.11）（趋势P = 0.82）男性和1.02（0.90至1.16）至0.97（0.85至1.11;趋势P = 0.37）。结论-这些数据没有提供任何证据表明咖啡消费增加冠心病的风险。
Background - We examined the association between long-term habitual coffee consumption and risk of coronary heart disease (CHD).Methods and Results - We performed a prospective cohort study with 44 005 men and 84 488 women without history of cardiovascular disease or cancer. Coffee consumption was first assessed in 1986 for men and in 1980 for women and then repeatedly every 2 to 4 years; the follow-up continued through 2000. We documented 2173 incident cases of coronary heart disease (1449 nonfatal myocardial infarctions and 724 fatal cases of CHD) among men and 2254 cases ( 1561 nonfatal myocardial infarctions and 693 fatal cases of CHD) among women. Among men, after adjustment for age, smoking, and other CHD risk factors, the relative risks (RRs) of CHD across categories of cumulative coffee consumption (< 1 cup/mo, 1 cup/mo to 4 cups/wk, 5 to 7 cups/wk, 2 to 3 cups/d, 4 to 5 cups/d, and >= 6 cups/d) were 1.0, 1.04 (95% confidence interval 0.91 to 1.17), 1.02 (0.91 to 1.15), 0.97 (0.86 to 1.11), 1.07 (0.88 to 1.31), and 0.72 (0.49 to 1.07; P for trend = 0.41); among women, the RRs were 1.0, 0.97 (0.83 to 1.14), 1.02 (0.90 to 1.17), 0.84 (0.74 to 0.97), 0.99 (0.83 to 1.17), and 0.87 (0.68 to 1.11; P for trend = 0.08). Stratification by smoking status, alcohol consumption, history of type 2 diabetes mellitus, and body mass index gave similar results. Similarly, we found no effect when the most recent coffee consumption was examined. RRs for quintiles of caffeine intake varied from 0.97 ( 0.84 to 1.10) in the second quintile to 0.97 (0.84 to 1.11) in the highest quintile (P for trend = 0.82) in men and from 1.02 (0.90 to 1.16) to 0.97 (0.85 to 1.11; P for trend = 0.37) in women.Conclusions - These data do not provide any evidence that coffee consumption increases the risk of CHD.