Inhibitory effects of fermented brown rice on induction of acute colitis by dextran sulfate sodium in rats
Inhibitory effects of fermented brown rice on induction of acute colitis by dextran sulfate sodium in rats
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DOI：
10.1007/s10620-007-0063-3
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发表时间：
2008-06-01
影响因子：
3.1
通讯作者：
Ohnishi, Yoshinari
中科院分区：
文献类型：
--
作者：
Kataoka, Keiko;Ogasa, Sachiko;Ohnishi, Yoshinari
虽然炎症性肠病的致病机制尚未完全清楚，但结肠微生物群可能影响结肠炎症的诱导，一些益生菌和益生元已被报道可以抑制结肠炎。研究了富含纤维素的食品--曲霉发酵糙米（FBRA）对葡聚糖硫酸钠（DSS）诱导的急性结肠炎的抑制作用。喂食含有5%和10%FBRA的饲料可显着减少阿尔新蓝染色的大鼠结肠溃疡和糜烂面积。在另一个实验中，喂食10%FBRA降低了溃疡指数（溃疡总长度在结肠全长中的百分比）和结肠炎评分，这是通过肉眼观察确定的。它还降低了结肠粘膜中的髓过氧化物酶活性。给予DSS后，粪便中乳杆菌的活细胞数量减少，并与结肠炎的严重程度负相关，而肠杆菌科的细胞数量增加，并与结肠炎的严重程度正相关。这些结果表明，FBRA对DSS诱导结肠炎具有抑制作用，并表明FBRA介导的结肠微生物群的修饰。
Although the pathogenic mechanisms of inflammatory bowel diseases are not fully understood, colonic microbiota may affect the induction of colonic inflammation, and some probiotics and prebiotics have been reported to suppress colitis. The inhibitory effects of brown rice fermented by Aspergillus oryzae (FBRA), a fiber-rich food, on the induction of acute colitis by dextran sulfate sodium (DSS) were examined. Feeding a 5% and 10% FBRA-containing diet significantly decreased the ulcer and erosion area in the rat colon stained with Alcian blue. In another experiment, 10% FBRA feeding decreased the ulcer index (percentage of the total length of ulcers in the full length of the colon) and colitis score, which were determined by macroscopic observation. It also decreased myeloperoxidase activity in the colonic mucosa. Viable cell numbers of Lactobacillus in the feces decreased after DSS administration and was reversely correlated with severity of colitis, while the cell number of Enterobacteriaceae increased after DSS treatment and was positively correlated with colitis severity. These results indicate that FBRA has a suppressive effect on the induction of colitis by DSS and suggest FBRA-mediated modification of colonic microbiota.