Spatial and numerical regulation of flagellar biosynthesis in polarly flagellated bacteria.
Spatial and numerical regulation of flagellar biosynthesis in polarly flagellated bacteria.
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DOI：
10.1111/mmi.12221
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发表时间：
2013-05
影响因子：
3.6
通讯作者：
Hendrixson DR
中科院分区：
文献类型：
--
作者：
Kazmierczak BI;Hendrixson DR
控制表面细胞器的数量和位置是许多革兰氏阳性和革兰氏阴性细菌的细胞生物学的一个重要方面，但缺乏对细菌如何在空间和数字上组织细胞器的机械见解。许多表面结构和内部复合物在细菌细胞中受到空间限制（例如，IV型皮利、固着器、化学感受器），但也许没有一个像鞭毛那样在数量和定位方面表现出如此多的独特模式。在这篇综述中，我们讨论了两种蛋白质，FlhF和FlhG（也注释FleN/YlxH），控制方面的鞭毛组装，位置和数量在极性鞭毛虫，并可能影响鞭毛在一些细菌产生围毛鞭毛。在一些细菌物种中获得的实验数据表明，这些蛋白质可能已经获得了不同的属性影响鞭毛组装，反映了在不同的极性鞭毛虫中看到的鞭毛模式的多样性。最近的研究结果还表明FlhF和FlhG参与其他过程，如影响鞭毛的旋转和适当的细胞分裂。这些蛋白质在极性鞭毛虫的继续检查，预计将揭示不同的细菌如何适应FlhF或FlhG与特定的活动，以定制鞭毛的生物合成和运动，以适应每个物种的需要。
Control of surface organelle number and placement is a crucial aspect of the cell biology of many Gram-positive and Gram-negative bacteria, yet mechanistic insights into how bacteria spatially and numerically organize organelles are lacking. Many surface structures and internal complexes are spatially restricted in the bacterial cell (e.g., Type IV pili, holdfasts, chemoreceptors), but perhaps none show so many distinct patterns in terms of number and localization as the flagellum. In this review, we discuss two proteins, FlhF and FlhG (also annotated FleN/YlxH), which control aspects of flagellar assembly, placement, and number in polar flagellates, and may influence flagellation in some bacteria that produce peritrichous flagella. Experimental data obtained in a number of bacterial species suggest that these proteins may have acquired distinct attributes influencing flagellar assembly that reflect the diversity of flagellation patterns seen in different polar flagellates. Recent findings also suggest FlhF and FlhG are involved in other processes, such as influencing the rotation of flagella and proper cell division. Continued examination of these proteins in polar flagellates is expected to reveal how different bacteria have adapted FlhF or FlhG with specific activities to tailor flagellar biosynthesis and motility to fit the needs of each species.
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影响因子：
3.2
作者：
Dasgupta, N;Ramphal, R
通讯作者：
Ramphal, R
影响因子：
3.2
作者：
Correa, NE;Peng, F;Klose, KE
通讯作者：
Klose, KE
影响因子：
64.8
作者：
Egea, PF;Shan, SO;Stroud, RM
通讯作者：
Stroud, RM
影响因子：
3.6
作者：
Hendrixson, DR;DiRita, VJ
通讯作者：
DiRita, VJ
影响因子：
3.2
作者：
Balaban, Murat;Joslin, Stephanie N.;Hendrixson, David R.
通讯作者：
Hendrixson, David R.