Surviving cancer: A comparison of 5-year disease-free breast cancer survivors with healthy women
Surviving cancer: A comparison of 5-year disease-free breast cancer survivors with healthy women
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DOI：
10.1002/pon.848
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发表时间：
2005-04-01
期刊：
影响因子：
3.6
通讯作者：
Tomich, PL
中科院分区：
文献类型：
--
作者：
Helgeson, VS;Tomich, PL
患有乳腺癌的女性是癌症幸存者中最大的群体之一。这项研究通过比较5年无病幸存者和年龄匹配的对照组，以及比较复发的女性和无病幸存者，检验了乳腺癌是否对生活质量(QOL)产生了长期影响。对照组的招募采用邻里控制方法。在面谈中评估生活质量(身体、情感、社交和精神)。无病存活者(n=267)和对照组(n=187)在许多生活质量指标上无差异。然而，与对照组相比，幸存者报告了更多的身体功能障碍、更多的身体症状和更多的信念(均为PS<；0.05)。与无病存活者相比，复发存活者(n=37)在大多数指标上的生活质量更差，更少的积极情绪，更普遍的疲倦，更多的侵入性和回避性思维(均PS<；0.05)。两组幸存者在婚姻、工作经历或精神方面的指数没有差异。这些发现表明，除身体功能外，长期无病幸存者的生活质量与同龄女性相当。复发的女性在某些领域(但不是所有领域)的生活质量受到损害。版权所有(C)2004 John Wiley&Sons，Ltd.
Women with breast cancer are one of the largest groups of cancer survivors. This research examined whether breast cancer has a long-term impact on quality of life (QOL) by comparing 5-year disease-free survivors to age-matched controls and by comparing women who sustained a recurrence to disease-free survivors. Controls were recruited using the neighborhood control methodology. QOL (physical, emotional, social, and spiritual) was assessed during in-person interviews. There were no differences between disease-free survivors (n = 267) and controls (n = 187) on many indicators of QOL. However, survivors reported more difficulties with physical functioning, more physical symptoms, and more faith than did controls (all ps < 0.05). Compared to disease-free survivors, survivors with a recurrence (n = 37) had a worse QOL on most indices, less positive affect, more general fatigue, and more intrusive and avoidant thoughts (all ps < 0.05). There were no differences between the two groups of survivors on indices of marriage, work experiences, or spirituality. These findings suggest that the QOL of long-term survivors who remain disease-free is comparable to that of women their age with the exception of physical functioning. Women who sustain a recurrence suffer an impaired QOL in some, but not all, domains. Copyright (c) 2004 John Wiley & Sons, Ltd.