Class II antigens on canine T lymphocytes.
Class II antigens on canine T lymphocytes.
复制标题
犬 T 淋巴细胞上的 II 类抗原。
作者：
R. Doveren;W. Buurman;B. Schutte;G. Groenewegen;C. J. van der Linden
一组交叉反应的抗人，小鼠和大鼠MHC II类单克隆抗体（Mab）被用来检查犬T淋巴细胞的MHC II类抗原表达的细胞荧光测定法。在活化的T淋巴母细胞以及非刺激的外周血T淋巴细胞上证明了MHC II类抗原的存在。许多抗MHC II类单克隆抗体仅与活化的T淋巴母细胞反应。免疫沉淀研究证实了犬T细胞上抗原的Ia样或MHC II类分子特征。外周血T淋巴细胞上的MHC II类抗原的表达似乎不是由T细胞的刺激诱导的，因为无特定病原体的狗的纯化的T淋巴细胞与抗MHC II类单克隆抗体反应。此外，研究表明，MHC II类抗原表达存在于新生儿胸腺。凝集素刺激和同种异体刺激的T淋巴母细胞表现出较强的MHC II类抗原的表达与非刺激的T细胞相比。
A panel of crossreactive anti-human, -mouse and -rat MHC class II monoclonal antibodies (Mabs) was used to examine MHC class II antigen expression on canine T lymphocytes by cytofluorometry. The presence of MHC class II antigens was demonstrated on activated T lymphoblasts as well as on non-stimulated peripheral blood T lymphocytes. A number of anti-MHC class II Mabs reacted only with activated T lymphoblasts. Immunoprecipitation studies confirmed the Ia-like or MHC class II molecular character of the antigens on canine T cells. The expression of MHC class II antigens on peripheral blood T lymphocytes appeared to be not induced by stimulation of the T cells, as purified T lymphocytes of specific pathogen free dogs reacted with anti-MHC class II Mabs. Moreover, the study indicates that MHC class II antigen expression is present in the neonatal thymus. Lectin stimulated and allogeneically stimulated T lymphoblasts showed a stronger expression of MHC class II antigens in comparison with non-stimulated T cells.
识别犬和人类 Ia 样抗原的单克隆抗体。
影响因子：
6.2
作者：
Alejandro,R;Shienvold,FL;Latif,Z;Esquenazi,V;Miller,J;Mintz,DH
通讯作者：
Mintz,DH
通过二维凝胶电泳表征 HLA-D 区抗原。
DOI：
--
发表时间：
1980
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Charron,DJ;McDevitt,HO
通讯作者：
McDevitt,HO
通过单克隆抗体检测人类同种异体反应性 T 细胞上的 Ia 抗原。
DOI：
--
发表时间：
1980
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Charron,DJ;Engelman,EG;Benike,CJ;McDevitt,HO
通讯作者：
McDevitt,HO