Attenuation of radiation- and drug-induced conditioned taste aversions following area postrema lesions in the rat.
Attenuation of radiation- and drug-induced conditioned taste aversions following area postrema lesions in the rat.
复制标题
大鼠后区损伤后辐射和药物引起的条件性味觉厌恶的减弱。
作者：
B. Rabin;W. A. Hunt;J. Lee
研究了最后区病变对辐射和药物(组胺和氯化锂)诱导的条件性味觉厌恶获得的影响。结果表明，后皮损区显著减弱了通过将一种新的蔗糖溶液与辐射(100rad)或药物注射配对而产生的厌恶。此外，在所有三种治疗条件下，后皮损区域产生了类似程度的味觉厌恶减弱。根据这一发现对定义暴露于电离辐射可导致条件性味觉厌恶的机制的影响，对结果进行了讨论。
The effects of lesions of the area postrema on the acquisition of radiation- and drug-induced (histamine and lithium chloride) conditioned taste aversions were investigated. The results indicated that area postrema lesions caused a significant attenuation of the aversion produced by pairing a novel sucrose solution with radiation (100 rad) or drug injection. Further, the area postrema lesions produced a similar level of attenuation of the taste aversion in all three treatment conditions. The results are discussed in terms of the implications of this finding for defining the mechanisms by which exposure to ionizing radiation can lead to the acquisition of a conditioned taste aversion.