Can active components of licorice, glycyrrhizin and glycyrrhetinic acid, lick rheumatoid arthritis?
Can active components of licorice, glycyrrhizin and glycyrrhetinic acid, lick rheumatoid arthritis?
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甘草活性成分甘草甜素和甘草次酸能治疗类风湿关节炎吗？
DOI：
10.18632/oncotarget.6200
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发表时间：
2016-01-12
期刊：
影响因子：
--
通讯作者：
Huang RY
中科院分区：
文献类型：
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作者：
Huang QC;Wang MJ;Chen XM;Yu WL;Chu YL;He XH;Huang RY
该综述阐述了甘草活性成分甘草甜素（GL）和甘草次酸（GA）在基于环氧合酶（COX）-2/血栓烷A2（TxA2）途径的类风湿性关节炎（RA）治疗中的可能应用。在PubMed中心检索了从成立到2015年7月的大量文献，根据本研究的目的筛选出相关报道。甘草 GL 和 GA 的活性成分至少部分通过抑制 COX-2 及其下游产物 TxA2 发挥潜在的抗炎作用。此外，COX-2/TxA2 通路（一种自动调节反馈回路）最近被发现是 RA 发病机制的关键机制。然而，TxA2既不是非甾体抗炎药（NSAID）的药理学靶点，也不是疾病缓解抗风湿药（DMARD）的靶点，这些药物的局限性和副作用可能至少部分归因于缺乏对COX-2/TxA2通路的影响。因此，能够靶向该途径的 GL 和 GA 具有作为治疗策略中新型附加疗法的潜力，这得到了多项实验室实验的支持。甘草的活性成分GL和GA在RA治疗过程中不仅可以增强治疗效果，还可以通过抑制COX-2/TxA2通路来减少NSAIDs或DMARDs的不良反应。
This review stated the possible application of the active components of licorice, glycyrrhizin (GL) and glycyrrhetinic acid (GA), in rheumatoid arthritis (RA) treatment based on the cyclooxygenase (COX)-2/thromboxane A2 (TxA2) pathway. The extensive literature from inception to July 2015 was searched in PubMed central, and relevant reports were identified according to the purpose of this study. The active components of licorice GL and GA exert the potential anti-inflammatory effects through, at least in part, suppressing COX-2 and its downstream product TxA2. Additionally, the COX-2/TxA2 pathway, an auto-regulatory feedback loop, has been recently found to be a crucial mechanism underlying the pathogenesis of RA. However, TxA2 is neither the pharmacological target of non-steroidal anti-inflammatory drugs (NSAIDs) nor the target of disease modifying anti-rheumatic drugs (DMARDs), and the limitations and side effects of those drugs may be, at least in part, attributable to lack of the effects on the COX-2/TxA2 pathway. Therefore, GL and GA capable of targeting this pathway hold the potential as a novel add-on therapy in therapeutic strategy, which is supported by several bench experiments. The active components of licorice, GL and GA, could not only potentiate the therapeutic effects but also decrease the adverse effects of NSAIDs or DMARDs through suppressing the COX-2/TxA2 pathway during treatment course of RA.