MISMATCH REPAIR - MECHANISMS AND RELATIONSHIP TO CANCER SUSCEPTIBILITY
MISMATCH REPAIR - MECHANISMS AND RELATIONSHIP TO CANCER SUSCEPTIBILITY
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DOI：
10.1016/s0968-0004(00)89087-8
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发表时间：
1995-10-01
影响因子：
13.8
通讯作者：
KOLODNER, RD
中科院分区：
文献类型：
--
作者：
KOLODNER, RD
存在DNA错配修复系统，其修复在DNA复制、遗传重组期间以及由于DNA损伤而形成的错配碱基。这些系统的某些组分在原核生物和真核生物中是保守的。错配修复基因的遗传缺陷在常见的癌症易感综合征和散发性癌症中起着重要作用。
DNA mismatch-repair systems exist that repair mispaired bases formed during DNA replication, genetic recombination and as a result of damage to DNA. Some components of these systems are conserved in prokaryotes and eukaryotes. Genetic defects in mismatch-repair genes play an important role in common cancer-susceptibility syndromes and sporadic cancers.