Transcriptome Sequencing of the Anterior Cingulate in Bipolar Disorder: Dysregulation of G Protein-Coupled Receptors
Transcriptome Sequencing of the Anterior Cingulate in Bipolar Disorder: Dysregulation of G Protein-Coupled Receptors
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DOI：
10.1176/appi.ajp.2015.14101279
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发表时间：
2015-11-01
影响因子：
17.7
通讯作者：
Turecki, Gustavo
中科院分区：
文献类型：
--
作者：
Cruceanu, Cristiana;Tan, Powell Patrick Cheng;Turecki, Gustavo
目的：通过候选基因和微阵列表达研究，发现双相情感障碍与脑内基因表达异常有关，但目前尚不清楚非编码RNA在双相情感障碍中的作用，而非编码RNA在双相情感障碍中具有重要作用。计算差异表达，并检测到下调的全球模式，有10个转录本显著错误发现率
Objective: Gene expression dysregulation in the brain has been associated with bipolar disorder through candidate gene and microarray expression studies, but questions remain about isoform-specific dysregulation and the role of noncoding RNAs whose importance in the brain has been suggested recently but not yet characterized for bipolar disorder.Method: The authors used RNA sequencing, a powerful technique that captures the complexity of gene expression, in postmortem tissue from the anterior cingulate cortex from 13 bipolar disorder case subjects and 13 matched comparison subjects. Differential expression was computed, and a global pattern of downregulation was detected, with 10 transcripts significant at a false discovery rate