An Antimicrobial Dental Light Curable Bioadhesive Hydrogel for Treatment of Peri-Implant Diseases
An Antimicrobial Dental Light Curable Bioadhesive Hydrogel for Treatment of Peri-Implant Diseases
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DOI：
10.1016/j.matt.2019.07.019
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发表时间：
2019-10-02
期刊：
影响因子：
18.9
通讯作者：
Annabi, Nasim
中科院分区：
文献类型：
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作者：
Sani, Ehsan Shirzaei;Lara, Roberto Portillo;Annabi, Nasim
种植牙仍然是替代缺失牙齿的标准治疗方法，这导致受种植体周围疾病 (PID) 影响的患者数量增加。在此，我们报告了用于治疗 PID 的抗菌生物粘合剂 GeIAMP 的开发。该水凝胶基于可见光激活的天然聚合物（明胶）和抗菌肽（AMP）。 GeIAMP 的优化配方可以使用商业牙科固化系统快速交联。与商业粘合剂相比，GeIAMP 对生理组织和钛表面表现出明显更高的粘合力。此外，该生物粘合剂表现出较高的细胞相容性，能够有效促进体外细胞增殖和迁移。 GeIAMP 还对牙龈卟啉单胞菌表现出显着的抗菌活性。此外，它可以在封闭小鼠颅骨缺损后支持自体骨的生长。总体而言，GeIAMP 可以作为开发更有效的 PID 疗法的平台。
Dental implants remain the standard of care to replace missing teeth, which has led to an increase in the number of patients affected by peri-implant diseases (PIDs). Here, we report the development of an antimicrobial bioadhesive, GeIAMP, for the treatment of PIDs. The hydrogel is based on a visible-light-activated naturally derived polymer (gelatin) and an antimicrobial peptide (AMP). The optimized formulation of GeIAMP could be rapidly crosslinked using commercial dental curing systems. When compared with commercial adhesives, GeIAMP exhibited significantly higher adhesion to physiological tissues and titanium surfaces. Moreover, the bioadhesive showed high cytocompatibility and could efficiently promote cell proliferation and migration in vitro. GeIAMP also showed remarkable antimicrobial activity against Porphyromonas gingivalis. Furthermore, it could support the growth of autologous bone after sealing calvarial bone defects in mice. Overall, GeIAMP could be used as a platform for the development of more effective therapies against PIDs.