Association between maternal active smoking during pregnancy and placental weight: The Japan environment and Children's study
Association between maternal active smoking during pregnancy and placental weight: The Japan environment and Children's study
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DOI：
10.1016/j.placenta.2020.04.001
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发表时间：
2020-05-01
期刊：
影响因子：
3.8
通讯作者：
Suganuma, N.
中科院分区：
文献类型：
--
作者：
Mitsuda, N.;Awn, J. P. N.;Suganuma, N.
简介：众所周知，孕妇在怀孕期间吸烟是导致出生体重减轻的危险因素。然而，调查母亲吸烟和胎盘重量之间关系的研究很少，而且不一致。我们的研究进行了评估母亲吸烟和胎盘重量和胎盘重量/出生体重比（PW/BW ratio）之间的关联。方法：我们使用的数据来自出生队列研究，日本环境和儿童研究（JECS）。主要结果指标为胎盘重量、PW/BW比值和PW/BW比值高的风险。高PW/BW比定义为PW/BW比高于胎龄和后代性别的第90百分位数。母亲吸烟和胎盘重量之间的关联估计为粗和调整后的β系数应用线性回归分析。Logistic回归分析也进行了估计产妇吸烟和高PW/BW ratio.Results的风险之间的关联：91,951孕妇，平均胎盘重量和平均PW/BW比是最低的妇女组谁从来没有吸烟。与非吸烟者相比，吸烟者的PW/BW比值较高。此外，在吸烟者中，平均胎盘重量和平均PW/BW比最低的妇女谁吸烟少于5日香烟，最高的妇女谁吸烟20日或以上的香烟在pregnancy.Discussion：胎盘重量更大，PW/BW比吸烟者与非吸烟者相比更高。此外，每天吸烟的数量与胎盘重量呈正相关。
Introduction: Maternal smoking during pregnancy is a well-known risk factor for reduced birthweight. However, research investigating the association between maternal smoking and placental weight is scarce and inconsistent. Our study was conducted to evaluate the association between maternal smoking and placental weight and placental weight/birthweight ratio (PW/BW ratio).Methods: We used data from a birth cohort study, the Japan Environment and Children's Study (JECS). Main outcome measures were placental weight, PW/BW ratio, and the risk of high PW/BW ratio. High PW/BW ratio was defined as PW/BW ratio above the 90th percentile for gestational age and sex of offspring. The association between maternal smoking and placental weight was estimated as crude and as adjusted beta coefficients by applying linear regression analyses. Logistic regression analyses were also performed to estimate the association between maternal smoking and the risk of high PW/BW ratio.Results: Of the 91,951 pregnant women, the mean placental weight and the mean PW/BW ratio were lowest for the group of women who had never smoked. Smokers had higher odds ratio for high PW/BW ratio compared with non-smokers. Furthermore, among smokers, the mean placental weight and mean PW/BW ratio were lowest in women who smoked less than 5 daily cigarettes, and highest in women who smoked 20 or more daily cigarettes during pregnancy.Discussion: Placental weight was greater and PW/BW ratio was higher among smokers compared with nonsmokers. Moreover, the number of daily cigarettes was positively associated with heavy placental weight.