The effects of local application of D2 selective dopaminergic drugs into the medial prefrontal cortex of rats in a delayed spatial choice task
The effects of local application of D2 selective dopaminergic drugs into the medial prefrontal cortex of rats in a delayed spatial choice task
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DOI：
10.1016/s0166-4328(99)00166-7
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发表时间：
2000-04-01
影响因子：
2.7
通讯作者：
Kozlov, AP
中科院分区：
文献类型：
--
作者：
Druzin, MY;Kurzina, NP;Kozlov, AP
该研究检测了多巴胺D2受体介导的大鼠前额叶皮层（PFC）神经传递的调节对工作记忆的存储和执行成分的影响。对大鼠进行延迟选择（延迟间隔为3 s）和非延迟选择的u型迷宫训练。在先前试验中动物反应的基础上，通过对当前试验中的错误进行分类来评估主动干扰的重要性。将与前一实验相同的迷宫路径错误归为重复（RE），将与前一实验相比的迷宫路径错误归为改变（AE）。将D2激动剂PPHT （0.004 μ g、0.04 μ g、0.4 μ g/l μ l）双侧微量注入PFC内侧壁后，延迟反应任务的错误率呈剂量依赖性增加，但对非延迟选择没有影响。在延迟条件下，PPHT增强了选择的坚持倾向（RE率显著高于AE率），在非延迟条件下，错误表现主要以AE为代表。相反，注射d2受体拮抗剂舒必利(0.03 μ g, 0.3 μ g，3 μ g/l μ l)提高了延迟选择的准确性，改变了试验间依赖模式——AE显著高于RE。从D2受体依赖的PFC传递参与与u型迷宫延迟表现相关的不同认知过程（试验内短期信息存储与试验间工作记忆加工的动态控制）的角度讨论了这一结果。(C) 2000爱思唯尔科学爱尔兰有限公司版权所有。
The study examined the effects of modulation of dopamine D2 receptors-mediated neurotransmission in the rat's prefrontal cortex (PFC) on storage and executive components of working memory. Rats were trained on delayed (delay interval, 3 s) and non-delayed choice in a U-maze. The prominence of proactive interference was evaluated by sorting errors in a current trial on the basis of animal reactions in a preceding trial. The erroneous runs to the same arm of the maze as in the previous trial were identified as the repetitions (RE) and the erroneous runs to the other arm in comparison with the previous trial were classified as alternations (AE). The bilateral microinfusion of D2 agonists PPHT (0.004 mu g, 0.04 mu g, 0.4 mu g/l mu l) into medial wall of the PFC produced a dose-dependent increase in the error rate of the delayed-response task and did not influence non-delayed choice. In delay condition PPHT enhanced the perseverative tendencies (the rate of RE was significantly higher than the rate of AE), in non-delayed choice the erroneous performance was mainly represented by AE. In contrast, the infusion of D2-receptor antagonist sulpiride (0.03 mu g, 0.3 mu g, 3 mu g/l mu l) increased the accuracy of delayed choice and changed the mode of intertrial dependence-rats made significantly more AE than RE. The results are discussed in terms of the involvement of D2 receptor dependent transmission of the PFC in different cognitive processes related to the delayed performance in U-maze (within-trial short-term storage of information versus dynamic control of between-trials working memory processing). (C) 2000 Elsevier Science Ireland Ltd. Ail rights reserved.