Prospective evaluation of the angiotensin-converting enzyme insertion/deletion polymorphism and the risk of stroke.
Prospective evaluation of the angiotensin-converting enzyme insertion/deletion polymorphism and the risk of stroke.
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DOI：
10.1161/01.cir.99.3.340
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发表时间：
1999-01
期刊：
影响因子：
37.8
通讯作者：
R. Zee;P. Ridker;M. Stampfer;C. H. Hennekens;Klaus Lindpaintner
中科院分区：
文献类型：
--
作者：
R. Zee;P. Ridker;M. Stampfer;C. H. Hennekens;Klaus Lindpaintner
BACKGROUND The D/I polymorphism of the ACE gene has been studied in relation to a variety of cardiovascular disorders, including stroke. A number of small studies have been conducted, with inconsistent results. We investigated the association between ACE genotype and the incidence of stroke in a large, prospective, matched case-control sample from the Physicians' Health Study. METHODS AND RESULTS In the Physicians' Health Study, 348 subjects who had been apparently healthy at enrollment suffered a stroke during 12 years of follow-up, as determined from medical records and autopsy. A total of 348 cases were matched by age, time of randomization, and smoking habit to an equal number of controls (who had remained free of stroke). The D/I polymorphism was determined by polymerase chain reaction. Data were analyzed for the entire nested case-control sample, and also among a subgroup without a history of hypertension or diabetes mellitus, considered to be at low conventional risk (207 cases and 280 controls). All observed genotype frequencies were in Hardy-Weinberg equilibrium. The relative risk associated with the D allele was 1.11 (95% CI, 0.90 to 1.37; P=0.35), assuming an additive model in the matched analysis. Additional analyses assuming dominant or recessive effects of the D allele, as well as the analysis after stratification for low-risk status, showed no material as a statistically significant association. CONCLUSIONS The results of this large, prospective study indicate that the ACE D/I gene polymorphism is not associated with subsequent risk of stroke.
