Developmental parameters of cell death in the wing disc of Drosophila
Developmental parameters of cell death in the wing disc of Drosophila
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DOI：
10.1073/pnas.94.11.5691
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发表时间：
1997-05-27
影响因子：
11.1
通讯作者：
GarciaBellido, A
中科院分区：
文献类型：
--
作者：
Milan, M;Campuzano, S;GarciaBellido, A
翅盘中的细胞凋亡发生在单个细胞或相邻细胞的小簇中。这些细胞分布在整个原基在早期阶段和可识别的领土在晚期幼虫和蛹阶段。在被血淋巴细胞吞噬之前，凋亡细胞在上皮中保留2-4小时。实验诱导的单个细胞或区域的凋亡伴随着相邻细胞和相邻区域中更远的细胞的非自主性死亡。这些影响之后，在两个领域的细胞增殖的变化，在突变盘的表生嵌合体显示整个原基的细胞死亡。除了细胞增殖控制之外，细胞凋亡还提供了一种机制，用于匹配具有不同位置值或不同遗传规格的区域。
Apoptotic cell death in wing imaginal discs takes place in single cells or small clusters of neighboring cells. These cells are distributed throughout the anlage at early stages and in recognizable territories at late larval and pupal stages. Apoptotic cells remain in the epithelium 2-4 h, prior to being engulfed in place by hemolymph cells, Experimentally induced apoptosis in single cells or territories is accompanied by nonautonomous death of adjacent cells and of cells further away in adjacent territories. These effects are followed by changes in cell proliferation in both territories, Apogenetic mosaics in mutant discs show cell death throughout the anlage. Apoptosis provides a mechanism, in addition to cell proliferation control, for matching territories with different positional values or different genetic specifications.