Electrospray for generation of drug delivery and vaccine particles applied in vitro and in vivo.
Electrospray for generation of drug delivery and vaccine particles applied in vitro and in vivo.
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DOI：
10.1016/j.msec.2019.110070
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发表时间：
2019-12
期刊：
影响因子：
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通讯作者：
Rebeca T. Steipel;M. Gallovic;Cole J. Batty;E. Bachelder;K. Ainslie
中科院分区：
文献类型：
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作者：
Rebeca T. Steipel;M. Gallovic;Cole J. Batty;E. Bachelder;K. Ainslie
也被称为电喷雾，电流体动力雾化在过去的15 年里被广泛用于开发用于细胞和动物模型中药物输送的聚合物基颗粒。最近，新型核-壳、多轴和其他电喷雾颗粒已经从一系列聚合物中开发出来，用于各种生物医学应用。本文重点介绍了电喷雾作为一种新型的药物递送颗粒制造方法，特别强调了这些颗粒系统在细胞培养和动物模型中的应用，同时也讨论了用于颗粒制造的聚合物。综述了电喷雾颗粒在胶质瘤、卵巢癌和乳腺癌治疗中的应用。此外，递送抗生素，基因治疗和细菌细胞配制的电喷雾颗粒进行了讨论。最后，疫苗以及用于干细胞分化和组织工程的药物洗脱颗粒被强调。文章最后讨论了电喷雾技术的未来，以加强其在生物医学领域的立足点。
Also known as electrospray, electrohydrodynamic atomization has been used extensively in the last 15 years to develop polymer-based particles for drug delivery in cell and animal models. More recently, novel core-shell, multi-axial, and other electrospray particles have been developed from an array of polymers for a variety of biomedical applications. This review focuses on electrospray as a novel method of particle fabrication for drug delivery, specifically highlighting the applications of these particle systems in cell culture and animal models while also discussing polymers used for particle fabrication. Applications of electrospray particles to treat glioma, ovarian cancer, and breast cancer are reviewed. Additionally, delivery of antibiotics, gene therapy, and bacterial cells formulated in electrospray particles is discussed. Finally, vaccines as well as drug eluting particles for differentiation of stem cells and tissue engineering are highlighted. The article concludes with a discussion of where the future of electrospray technology can go to strengthen its foothold in the biomedical field.