Specificity and strength of retinogeniculate connections.
Specificity and strength of retinogeniculate connections.
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DOI：
10.1152/jn.1999.82.6.3527
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发表时间：
1999-12
影响因子：
2.5
通讯作者：
W. Usrey;J. Reppas;And R Clay Reid;W. Usrey;John B Martin;R. Reppas;Reid Clay;Specificity
中科院分区：
文献类型：
--
作者：
W. Usrey;J. Reppas;And R Clay Reid;W. Usrey;John B Martin;R. Reppas;Reid Clay;Specificity
丘脑外侧膝状核 (LGN) 主要层中的视网膜神经节细胞及其目标神经元具有非常相似的中心环绕感受野。尽管一些膝状神经元由单个视网膜传入神经支配，但其他神经元则从多个视网膜传入神经元接收强输入和弱输入。在本研究中，在猫身上进行了实验，检查视网膜神经节细胞与其目标神经元之间单突触连接的特异性和强度。研究了 205 对具有重叠感受野中心或周围的视网膜神经节细胞和膝状神经元的反应。使用白噪声刺激定量绘制感受野；通过交叉关联视网膜和膝状棘突序列来评估连通性。在 205 对中，有 12 对被确定具有单突触连接。随着视网膜和膝状体感受野之间相似性的增加，细胞连接的可能性和连接的强度都增加。中心之间空间重叠度小于 50% 的细胞之间从未发现连接。结果表明，尽管膝状神经元经常接收来自多个视网膜传入的输入，但这些多个传入代表了具有重叠感受野中心的视网膜神经节细胞的选定子集。
Retinal ganglion cells and their target neurons in the principal layers of the lateral geniculate nucleus (LGN) of the thalamus have very similar, center-surround receptive fields. Although some geniculate neurons are dominated by a single retinal afferent, others receive both strong and weak inputs from several retinal afferents. In the present study, experiments were performed in the cat that examined the specificity and strength of monosynaptic connections between retinal ganglion cells and their target neurons. The responses of 205 pairs of retinal ganglion cells and geniculate neurons with overlapping receptive-field centers or surrounds were studied. Receptive fields were mapped quantitatively using a white-noise stimulus; connectivity was assessed by cross-correlating the retinal and geniculate spike trains. Of the 205 pairs, 12 were determined to have monosynaptic connections. Both the likelihood that cells were connected and the strength of connections increased with increasing similarity between retinal and geniculate receptive fields. Connections were never found between cells with <50% spatial overlap between their centers. The results suggest that although geniculate neurons often receive input from several retinal afferents, these multiple afferents represent a select subset of the retinal ganglion cells with overlapping receptive-field centers.