Cell communication networks in cancer invasion
Cell communication networks in cancer invasion
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DOI：
10.1016/j.ceb.2011.04.010
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发表时间：
2011-10-01
影响因子：
7.5
通讯作者：
Sahai, Erik
中科院分区：
文献类型：
--
作者：
Calvo, Fernando;Sahai, Erik
癌症的侵袭是一个重大的临床问题。现在很明显，侵袭不仅仅是癌细胞的自主过程，而是依赖于旁分泌相互作用的复杂网络。此外，这个网络会随着癌细胞的扩散而改变。在这里，我们总结了网络的关键组件及其通信机制。最后，我们讨论了癌症治疗过程中这种复杂的相互作用网络所带来的困难和机遇。
The invasion of cancer is a major clinical problem. It is now apparent that invasion is not a simply a cancer cell autonomous process but relies on a complex network of paracrine interactions. Furthermore, this network can change as cancer cells disseminate. Here we summarise the key components of the network and their mechanisms of communication. Finally, we discuss the difficulties and opportunities that this complex network of interactions presents during cancer therapy.