Pharmacology of the sphingosine-1-phosphate signalling system.
Pharmacology of the sphingosine-1-phosphate signalling system.
复制标题
1-磷酸鞘氨醇信号系统的药理学
DOI：
10.1007/978-3-7091-1368-4_13
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发表时间：
2013
影响因子：
--
通讯作者：
Pfeilschifter J
中科院分区：
文献类型：
--
作者：
Meyer zu Heringdorf D;Ihlefeld K;Pfeilschifter J
FTY720 （Fingolimod, Gilenya®）已被批准用于治疗复发-缓解型多发性硬化症，是同类首个鞘氨醇-1-磷酸（S1P）受体调节药物，最近的成功提高了该领域进一步药物开发的兴趣。几种选择性s1p1受体调节药物正在临床试验中研究，用于治疗各种自身免疫性疾病。鞘氨醇激酶抑制剂正在开发中，用于治疗癌症、异常血管生成和炎症性疾病；一种相对低亲和力的SK2抑制剂正在晚期实体瘤患者中进行分析。虽然间接的S1P裂解酶抑制剂在类风湿关节炎患者中的概念验证刚刚失败，但S1P裂解酶仍然是治疗炎症和自身免疫性疾病的有希望的靶点。另一种方法是开发S1P清除或清除剂，包括已成功通过I期临床试验的单克隆S1P抗体，并将进一步开发用于治疗年龄相关性黄斑变性。
The recent success of FTY720 (Fingolimod, Gilenya®), which has been approved for the treatment of relapsing–remitting multiple sclerosis and is the first-in-class sphingosine-1-phosphate (S1P) receptor modulating drug, has boosted the interest in further drug development in this area. Several selective S1P1receptor-modulating drugs are being investigated in clinical trials for the treatment of diverse autoimmune disorders. Sphingosine kinase inhibitors are under development for the treatment of cancer, aberrant angiogenesis and inflammatory diseases; an inhibitor of SK2 with relatively low affinity is being analysed in patients with advanced solid tumours. While an indirect S1P lyase inhibitor has just failed the proof of concept in patients with rheumatoid arthritis, S1P lyase is still a promising target for the treatment of inflammatory and autoimmune diseases. Another approach is the development of S1P-scavenging or -clearing agents, including a monoclonal S1P antibody that has successfully passed phase I clinical trials and will be further developed for age-related macular degeneration.
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影响因子：
13.5
作者：
Edmonds, Yvette;Milstien, Sheldon;Spiegel, Sarah
通讯作者：
Spiegel, Sarah
影响因子：
5.6
作者：
G. Tarrasón;M. Aulí;Sanam Mustafa;V. Dolgachev;M. T. Domenech;N. Prats;María Domínguez;Rosa López;Nuria Aguilar;M. Calbet;M. Pont;G. Milligan;S. Kunkel;N. Godessart
通讯作者：
G. Tarrasón;M. Aulí;Sanam Mustafa;V. Dolgachev;M. T. Domenech;N. Prats;María Domínguez;Rosa López;Nuria Aguilar;M. Calbet;M. Pont;G. Milligan;S. Kunkel;N. Godessart
影响因子：
3.4
作者：
Caballero, Sergio;Swaney, James;Moreno, Kelli;Afzal, Aqeela;Kielczewski, Jennifer;Stoller, Glenn;Cavalli, Amy;Garland, William;Hansen, Genevieve;Sabbadini, Roger;Grant, Maria B.
通讯作者：
Grant, Maria B.
影响因子：
7.3
作者：
Bolli, Martin H.;Abele, Stefan;Weller, Thomas
通讯作者：
Weller, Thomas
影响因子：
11.2
作者：
K. French;Randy S. Schrecengost;Brian D. Lee;Zhuang Yan;Staci N Smith;Justin L Eberly;Jong K. Yun
通讯作者：
K. French;Randy S. Schrecengost;Brian D. Lee;Zhuang Yan;Staci N Smith;Justin L Eberly;Jong K. Yun