3D Cine Phase-Contrast MRI at 3T in Intracranial Aneurysms Compared with Patient-Specific Computational Fluid Dynamics
3D Cine Phase-Contrast MRI at 3T in Intracranial Aneurysms Compared with Patient-Specific Computational Fluid Dynamics
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DOI：
10.3174/ajnr.a3484
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发表时间：
2013-09-01
影响因子：
3.5
通讯作者：
Nederveen, A. J.
中科院分区：
文献类型：
--
作者：
van Ooij, P.;Schneiders, J. J.;Nederveen, A. J.
背景和目的：CFD已被证明对模拟颅内动脉瘤中的血流有价值，这可能有助于更好地评估破裂风险。然而，CFD具有缺点，例如对模型所需的假设的敏感性，这可能会阻碍其临床实施。3D PC-MR成像是一种能够测量血流的技术。本研究的目的是比较流动模式的基础上，3D PC-MR成像与CFD estimations.MATERIALS和方法：3D PC-MR成像进行了8个颅内动脉瘤。从单独的2D PC-MR成像序列（2D CFD）和3D PC-MR成像（3D CFD）数据中获得了CFD的两组患者特定流入边界。通过计算速度矢量幅度和角度之间的差异，比较3D PC-MR成像和CFD。通过计算奇异流动能量来确定表示为涡流的存在和强度的流动模式的差异。结果：在收缩期，流动特征，如涡流模式是相似的。由于低速度噪声比，3D PC-MR成像测量结果出现不一致。对于2D CFD和3D CFD，收缩期速度幅度的相对差异分别为67.6 ± 51.4%和27.1 ± 24.9%，舒张期速度幅度的相对差异分别为33.7 ± 21.5%和17.7 ± 10.2%。对于单一能量，收缩期降低至15.5 +/- 13.9%，舒张末期降低至19.4 +/- 17.6%（2D CFD）。在收缩期，3D PC-MR成像和CFD在流型可视化和奇异能量计算方面具有良好的一致性。由于低的速度噪声比，3D PC-MR成像的流动模式不同于从CFD获得的流动模式。
BACKGROUND AND PURPOSE: CFD has been proved valuable for simulating blood flow in intracranial aneurysms, which may add to better rupture risk assessment. However, CFD has drawbacks such as the sensitivity to assumptions needed for the model, which may hinder its clinical implementation. 3D PC-MR imaging is a technique that enables measurements of blood flow. The purpose of this study was to compare flow patterns on the basis of 3D PC-MR imaging with CFD estimates.MATERIALS AND METHODS: 3D PC-MR imaging was performed in 8 intracranial aneurysms. Two sets of patient-specific inflow boundaries for CFD were obtained from a separate 2D PC-MR imaging sequence (2D CFD) and from the 3D PC-MR imaging (3D CFD) data. 3D PC-MR imaging and CFD were compared by calculation of the differences between velocity vector magnitudes and angles. Differences in flow patterns expressed as the presence and strengths of vortices were determined by calculation of singular flow energy.RESULTS: In systole, flow features such as vortex patterns were similar. In diastole, 3D PC-MR imaging measurements appeared inconsistent due to low velocity-to-noise ratios. The relative difference in velocity magnitude was 67.6 51.4% and 27.1 +/- 24.9% in systole and 33.7 +/- 21.5% and 17.7 +/- 10.2% in diastole for 2D CFD and 3D CFD, respectively. For singular energy, this was reduced to 15.5 +/- 13.9% at systole and 19.4 +/- 17.6% at diastole (2D CFD).CONCLUSIONS: In systole, good agreement between 3D PC-MR imaging and CFD on flow-pattern visualization and singular-energy calculation was found. In diastole, flow patterns of 3D PC-MR imaging differed from those obtained from CFD due to low velocity-to-noise ratios.