Metabolic and Community Synergy of Oral Bacteria in Colorectal Cancer.
Metabolic and Community Synergy of Oral Bacteria in Colorectal Cancer.
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DOI：
10.1128/msphere.00102-16
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发表时间：
2016-05
期刊：
影响因子：
4.8
通讯作者：
Schloss PD
中科院分区：
文献类型：
--
作者：
Flynn KJ;Baxter NT;Schloss PD
口腔牙周病变细菌核梭杆菌已多次与结直肠肿瘤有关。分子分析已经确定了促进结肠肿瘤形成的特定毒力因子。然而，其他口腔社区成员，如卟啉单胞菌属的成员，也在结肠肿瘤上发现了具有F·G核素的成员，因此，对个别病原体的狭隘研究没有考虑到社区范围的毒力特性。对口腔细菌生理和发病机制的更广泛的看法确定了两个因素，可以促进口腔细菌群落在结肠中的定植和持久性。口腔生物膜的多微生物性质和其中许多物种的阿糖分解代谢使它们非常适合在结肠病变的微环境中生活。这两个因素的考虑为口腔微生物区系在结直肠癌的发生、发展和治疗中的作用提供了一个新的视角。
The oral periodontopathic bacterium Fusobacterium nucleatum has been repeatedly associated with colorectal tumors. Molecular analysis has identified specific virulence factors that promote tumorigenesis in the colon. However, other oral community members, such as members of the Porphyromonas spp., are also found with F. nucleatum on colonic tumors, and thus, narrow studies of individual pathogens do not take community-wide virulence properties into account. A broader view of oral bacterial physiology and pathogenesis identifies two factors that could promote colonization and persistence of oral bacterial communities in the colon. The polymicrobial nature of oral biofilms and the asaccharolytic metabolism of many of these species make them well suited to life in the microenvironment of colonic lesions. Consideration of these two factors offers a novel perspective on the role of oral microbiota in the initiation, development, and treatment of colorectal cancer.