Scardovia wiggsiae and its potential role as a caries pathogen.
Scardovia wiggsiae and its potential role as a caries pathogen.
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DOI：
10.1016/j.job.2017.05.002
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发表时间：
2017-08
影响因子：
2.4
通讯作者：
Tanner ACR
中科院分区：
文献类型：
--
作者：
Kressirer CA;Smith DJ;King WF;Dobeck JM;Starr JR;Tanner ACR
变形链球菌与龋齿密切相关，但在没有变形链球菌的情况下也会发生龋齿。一个新的物种，Scardovia wiggsiae与儿童龋齿的关联表明，这可能是一个新的龋齿病原体。S.基于其与龋齿的关联以及其产生酸、在低pH环境中存活以及在实验动物中诱导龋齿的能力，变形杆菌被认为是龋齿病原体。S.在存在和不存在S.变种人进一步S。wiggsiae在使用固定正畸矫治器的青少年的初始龋损中升高。S.在低pH琼脂上富集wiggsiae检测，表明耐酸。S. wiggsiae分离物是耐酸性的，在低初始pH值下从几种糖产生酸，并且不是精氨酸脱亚胺酶阳性的，这些特征与潜在的致龋性一致。S. wiggsiae在大鼠动物模型中与S.变种人而S.当与S.变形杆菌，有显着的空腔生产。S. wiggsiae与晚期和初始龋齿有关，是耐酸的，在初始中性和低pH条件下产生酸至低pH。结合S. mutans、S.在动物模型的龋齿中检测到wiggsiae。总之，这些数据表明，S。wiggsiae具有许多与其作为龋齿相关物种相一致的特征。
Streptococcus mutans has been strongly associated with dental caries but caries also occurs in its absence. Association of a new species, Scardovia wiggsiae with childhood caries suggests this could be a new caries pathogen. S. mutans is considered a caries pathogen based on its association with caries, and on its ability to produce acid, to survive low pH environments, and to induce caries in experimental animals. S. wiggsiae was significantly associated with severe-early childhood caries in the presence and absence of S. mutans. Further S. wiggsiae was elevated in initial carious lesions in adolescents with fixed orthodontic appliances. S. wiggsiae detection was enriched on a low pH agar suggesting acid-tolerance. S. wiggsiae isolates were acid tolerant and produced acid from several sugars at low initial pH values, and were not arginine deiminase positive, characteristics consistent with potential cariogenicity. Cariogenicity of S. wiggsiae was tested in a rat animal model in parallel with S. mutans. While S. wiggsiae by itself showed minimal caries induction, when co-inoculated with S. mutans, there was significant cavity production. S. wiggsiae was associated with advanced and initial caries, is acid tolerant and produces acid to low pH at initial neutral and low pH conditions. In combination with S. mutans, S. wiggsiae was detected in caries in an animal model. Together, these data suggest that S. wiggsiae has many of the characteristics consistent with its being a caries-associated species.