cGAS goes viral: A conserved immune defense system from bacteria to humans.
cGAS goes viral: A conserved immune defense system from bacteria to humans.
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DOI：
10.1016/j.molcel.2023.12.005
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发表时间：
2024-01
期刊：
影响因子：
16
通讯作者：
Justin Jenson;Zhijian J. Chen
中科院分区：
文献类型：
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作者：
Justin Jenson;Zhijian J. Chen
为了生存，所有的生物都需要准确识别和中和病原体的能力。因此，我们的先天免疫系统用来对抗感染的许多基本策略都有深刻的进化根源。先天免疫传感器环状GMP-AMP合成酶(CGAS)是一种在我们的身体中发挥关键作用的酶，它通过感知和信号来响应微生物的感染，在许多脊椎动物、无脊椎动物甚至细菌中都具有广泛的保守性和功能同源性。在这篇综述中，我们将在讨论细菌中的cGAS同源物之前，对真核生物中的cGAS和cGAS样信号进行概述。
To survive, all organisms need the ability to accurately recognize and neutralize pathogens. As a result, many of the fundamental strategies that our innate immune system uses to fight infection have deep evolutionary roots. The innate immune sensor cyclic-GMP-AMP synthase (cGAS), an enzyme that plays a critical role in our bodies by sensing and signaling in response to microbial infection, is broadly conserved and has functional homologs in many vertebrates, invertebrates, and even bacteria. In this review, we will provide an overview of cGAS and cGAS-like signaling in eukaryotes before discussing cGAS-like homologs in bacteria.