The Aging Epigenome.
The Aging Epigenome.
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DOI：
10.1016/j.molcel.2016.05.013
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发表时间：
2016-06-02
期刊：
影响因子：
16
通讯作者：
Brunet A
中科院分区：
文献类型：
--
作者：
Booth LN;Brunet A
在衰老过程中，通常维持健康和抗压力的机制显著下降，导致衰老，虚弱，最终死亡。这种下降的确切时间和方式尚不清楚。转录网络和染色质状态的变化是年龄依赖性衰退的核心。这些表观基因组变化不仅在衰老过程中观察到，而且还深刻地影响细胞功能和抗应激能力，从而促进衰老的进展。我们认为转录和染色质网络的失调是衰老的重要组成部分。了解年龄依赖性表观基因组变化将对衰老如何开始和进展产生关键的见解，并应导致开发新的治疗方法，延迟甚至逆转衰老和年龄相关疾病。
During aging, the mechanisms that normally maintain health and stress resistance strikingly decline, resulting in decrepitude, frailty, and ultimately death. Exactly when and how this decline occurs is unknown. Changes in transcriptional networks and chromatin state lie at the heart of age-dependent decline. These epigenomic changes are not only observed during aging but also profoundly affect cellular function and stress resistance, thereby contributing to the progression of aging. We propose that the dysregulation of transcriptional and chromatin networks is a crucial component of aging. Understanding age-dependent epigenomic changes will yield key insights into how aging begins and progresses and should lead to the development of new therapeutics that delay or even reverse aging and age-related diseases.