Recurrent strokes in two patients with POEMS syndrome and Castleman's disease.
Recurrent strokes in two patients with POEMS syndrome and Castleman's disease.
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DOI：
10.1016/j.jstrokecerebrovasdis.2007.08.002
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发表时间：
2007-11-01
期刊：
影响因子：
--
通讯作者：
Biller, Jose
中科院分区：
文献类型：
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作者：
Garcia, Tracey;Dafer, Rima;Biller, Jose
POEMS综合征是一种以多发性神经病、器官肿大、内分泌病、单克隆丙种球蛋白病和皮肤改变为特征的疾病。Castleman病是一种罕见的淋巴组织增生性疾病，可出现在POEMS综合征患者中。以前的病例报告已经证明了POEMS综合征与冠状动脉和下肢动脉的动脉和静脉血栓形成之间的联系。然而，只有3例患者曾被描述为POEMS综合征，Castleman病和中风。本文报道了另外两名患有这种疾病组合的患者。我们怀疑中风是可能的颅内血管病变过程的结果。
POEMS syndrome is a disorder characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes. Castleman's disease is a rare lymphoproliferative disorder that can be present in patients with POEMS syndrome. Previous case reports have documented the association between POEMS syndrome and arterial and venous thromboses of the coronary and lower limb arteries. However, only 3 patients have ever been described with POEMS syndrome, Castleman's disease, and stroke. Two additional patients with this combination of disorders are reported herein. We suspect that the strokes are a result of a possible intracranial vasculopathic process.