The Genetic Basis of Type 2 Diabetes.
The Genetic Basis of Type 2 Diabetes.
复制标题
DOI：
10.1901/jaba.2006.2-100
复制
发表时间：
2006-04
期刊：
影响因子：
--
通讯作者：
S. Das;S. Elbein
中科院分区：
文献类型：
--
作者：
S. Das;S. Elbein
2型糖尿病是由复杂的生理过程引起的，包括胰腺β细胞、肌肉中的外周葡萄糖摄取、脂肪细胞分泌多种细胞因子和胰岛样分子、肝葡萄糖产生以及可能的中枢神经系统。与复杂的生理缺陷网络相一致，遗传学的新图景将涉及大量的风险易感基因，每个基因的影响相对较小（在大多数情况下，比值比低于1.2）。未来的挑战将包括编目和确认遗传风险因素，并了解这些风险因素如何相互作用，以及与已知的环境和生活方式风险因素相互作用，增加2型糖尿病的倾向。
Type 2 Diabetes results from a complex physiologic process that includes the pancreatic beta cells, peripheral glucose uptake in muscle, the secretion of multiple cytokines and hormone-like molecules from adipocytes, hepatic glucose production, and likely the central nervous system. Consistent with the complex web of physiologic defects, the emerging picture of the genetics will involve a large number of risk susceptibility genes, each individually with relatively small effect (odds ratios below 1.2 in most cases). The challenge for the future will include cataloging and confirming the genetic risk factors, and understanding how these risk factors interact with each other and with the known environmental and lifestyle risk factors that increase the propensity to type 2 diabetes.