Female sexual dysfunction: therapeutic options and experimental challenges.
Female sexual dysfunction: therapeutic options and experimental challenges.
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DOI：
10.2174/187152509789541882
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发表时间：
2009-10
影响因子：
--
通讯作者：
Webb RC
中科院分区：
文献类型：
--
作者：
Allahdadi KJ;Tostes RC;Webb RC
女性性功能障碍(FSD)是一个普遍存在的问题，大约40%的女性受到困扰，治疗方案很少。随着女性年龄的增长，FSD更为典型，是一种进行性和广泛性的疾病。与性功能障碍相关的常见症状包括阴道润滑性减少、性交时疼痛和不适、性唤醒意识减弱和难以达到性高潮。只有一小部分女性寻求医疗服务。与压倒性地研究和治疗男性勃起功能障碍，特别是开发磷酸二酯酶5型抑制剂相比，关于FSD的探索明显较少，治疗主要限于心理治疗。几种心血管疾病与FSD有关，包括动脉粥样硬化、外周动脉疾病和高血压，所有这些都是与男性衰老和勃起功能障碍相关的病理状况。通过动物模型，我们扩大了对FSD的理解，然而，为了正确治疗患有FSD的女性，仍有大量的知识需要了解。这篇综述的目的是提供有关FSD的最新知识，解决这种功能障碍的基础科学进展，并探索开发治疗方案。
Female sexual dysfunction (FSD) is a prevalent problem, afflicting approximately 40% of women and there are few treatment options. FSD is more typical as women age and is a progressive and widespread condition. Common symptoms associated with FSD include diminished vaginal lubrication, pain and discomfort upon intercourse, decreased sense of arousal and difficulty in achieving orgasm. Only a small percentage of women seek medical attention. In comparison to the overwhelming research and treatment for erectile dysfunction in males, specifically with the development of phosphodiesterase type 5 inhibitors, significantly less has been explored regarding FSD and treatment is primarily limited to psychological therapy. Several cardiovascular diseases have been linked with FSD including atherosclerosis, peripheral arterial disease and hypertension, all of which are also pathological conditions associated with aging and erectile dysfunction in men. Using animal models, we have expanded our understanding of FSD, however a tremendous amount is still to be learned in order to properly treat women suffering from FSD. The aim of this review is to provide the most current knowledge on FSD, advances in basic science addressing this dysfunction, and explore developing therapeutic options.