Clinical and demographic characterization of Jewish Crohn's disease patients in Israel
Clinical and demographic characterization of Jewish Crohn's disease patients in Israel
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DOI：
10.1097/00004836-200301000-00005
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发表时间：
2003-01-01
影响因子：
2.9
通讯作者：
Chowers, Y
中科院分区：
文献类型：
--
作者：
Fidder, HH;Avidan, B;Chowers, Y
背景：克罗恩病(CD)是一种病因不明的慢性跨壁炎症性疾病。遗传背景可能会影响疾病的性质。以色列的犹太人口由德系犹太人和塞法迪克犹太人组成，他们的基因背景不同。以前的研究报告说，Sephardic犹太人的CD患病率低于德系犹太人；然而，没有关于这些患者群体的疾病特征的信息。目的：评估以色列犹太患者中CD的人口学和临床特征。研究：我们对189例CD患者进行了观察。收集和分析人口学和临床数据。结果：48%的患者仅有回肠疾病。回肠狭窄发生率明显高于结肠疾病(分别为22%和3%，P=0.007)。没有发现当前吸烟和疾病严重程度之间的联系。Sephardic患者比德系患者更容易出现肠外疾病(分别为35%和17%，p=0.019)。结论：犹太以色列患者显示出仅回肠疾病的倾向。疾病的严重程度似乎不受吸烟的影响。这些疾病行为的差异可能与遗传因素有关。
Background: Crohn's disease (CD) is a chronic transmural inflammatory disease of unknown etiology. Genetic background may influence the nature of disease. The Jewish population in Israel is composed of Ashkenazi and Sephardic Jews, who differ in their genetic background. Previous studies have reported that the prevalence of CD in Sephardic Jews is lower than in Ashkenazi Jews; however, no information is available regarding disease characteristics in these patient populations. Goals: To assess the demographic and clinical characteristics of CD in Israeli Jewish patients. Study: We studied 189 CD patients who were observed in our department. Demographic and clinical data were collected and analyzed. Results: Forty-eight percent of the patients had ileum-only disease. Fistulizing disease was more frequently seen in ileocolonic than in ileal (p = 0.04) or colonic (p = 0.01) disease, whereas strictures occurred more often in ileal than in colonic disease (22% and 3%, respectively, p = 0.007). No association was found between current smoking and disease severity. Sephardic patients more frequently had extraintestinal disease than did Ashkenazi patients (35% vs. 17%, respectively, p = 0.019). Conclusion: Jewish Israeli patients show a predilection for ileum-only disease. Disease severity appears not to be influenced by smoking. These differences in disease behavior may be related to genetic factors.