Florida Aedes aegypti (Diptera: Culicidae) and Aedes albopictus Vector Competency for Zika Virus
Florida Aedes aegypti (Diptera: Culicidae) and Aedes albopictus Vector Competency for Zika Virus
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DOI：
10.1093/jme/tjy231
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发表时间：
2019-03-01
影响因子：
2.1
通讯作者：
Alto, Barry W.
中科院分区：
文献类型：
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作者：
Zimler, Rebecca A.;Alto, Barry W.
寨卡病毒 (ZIKV) 于 2013 年首次传播到巴西，目前已遍布美洲各地。 2016 年，佛罗里达州开始出现 ZIKV 本地传播。 2018年没有报告本地传播；然而，与旅行有关的案件仍在不断报告。在美国，本地传播的复发是佛罗里达州的一个主要公共卫生风险，该州媒介埃及伊蚊（双翅目：库蚊科，Linnaeus）和白纹伊蚊（双翅目：库蚊科，Skuse）数量丰富，病毒重新引入的可能性很高。剂量反应研究用于评估佛罗里达伊蚊的敏感性和传播潜力。埃及伊蚊和伊蚊。白纹伊蚊与源自波多黎各的寨卡病毒。蚊子口服暴露于三剂 ZIKV 中的一剂。较高剂量的受感染血液导致两种蚊子的总体感染率较高。艾。埃及伊蚊和伊蚊。白纹伊蚊对 ZIKV 感染敏感，并通过剂量相互作用揭示了一个重要的物种。低剂量时，Ae。埃及伊蚊明显比伊蚊更不易感染 ZIKV。白纹伊蚊（分别为 6.7% 和 44.4%）。相反，在高剂量下，Ae。埃及伊蚊明显比伊蚊更容易受到感染。白纹伊蚊（分别为 75.8% 和 53.8%）。 Ae 之间没有观察到显着差异。埃及伊蚊和伊蚊。白纹伊蚊的播散性感染（0-75%）和唾液感染（0-52.4%）。这些观察结果表明对伊蚊感染的敏感性更高。病毒血症人类可能会遇到较低剂量的白纹伊蚊。然而，伊蚊的播散性感染和唾液感染程度较低。白纹伊蚊与天主教的进食行为相结合，可能会限制相对于伊蚊的传播潜力。埃及伊蚊。
Zika virus (ZIKV) first spread into Brazil in 2013 and is now present throughout the Americas. In 2016, Florida witnessed the beginnings of local ZIKV transmission. No reports of local transmission have been reported for 2018; however, travel related cases continue to be reported. Recurrence of local transmission in the United States is a major public health risk in Florida where vectors Aedes aegypti (Diptera: Culicidae, Linnaeus) and Aedes albopictus (Diptera: Culicidae, Skuse) are abundant and there is a high potential for virus reintroduction. A dose-response study was used to evaluate susceptibility and transmission potential of Florida Ae. aegypti and Ae. albopictus to ZIKV originating from Puerto Rico. Mosquitoes were orally exposed to one of three doses of ZIKV. Higher doses of infected blood resulted in overall greater infection rates in both mosquito species. Ae. aegypti and Ae. albopictus were susceptible to infection with ZIKV and revealed a significant species by dose interaction. At low doses, Ae. aegypti was significantly less susceptible to infection with ZIKV than Ae. albopictus (6.7% and 44.4%, respectively). In contrast, at high doses, Ae. aegypti was significantly more susceptible to infection than Ae. albopictus (75.8% and 53.8%, respectively). No significant differences were observed between Ae. aegypti and Ae. albopictus in disseminated infection (0-75%) and saliva infection (0-52.4%). These observations suggest greater susceptibility to infection for Ae. albopictus at lower doses likely encountered by viremic humans. However, low disseminated infection and saliva infection for Ae. albopictus, combined with catholic feeding behavior, are likely to limit transmission potential relative to Ae. aegypti.