Estrogen therapy increases BDNF expression and improves post-stroke depression in ovariectomy-treated rats.
Estrogen therapy increases BDNF expression and improves post-stroke depression in ovariectomy-treated rats.
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DOI：
10.3892/etm.2016.3531
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发表时间：
2016-09
影响因子：
2.7
通讯作者：
Qiaoer Su;Yifan Cheng;K. Jin;Jianhua Cheng;Yuanshao Lin;Zhenzhen Lin;Liuqing Wang;B. Shao
中科院分区：
文献类型：
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作者：
Qiaoer Su;Yifan Cheng;K. Jin;Jianhua Cheng;Yuanshao Lin;Zhenzhen Lin;Liuqing Wang;B. Shao
本研究探讨外源性雌激素对卒中后抑郁的影响。大鼠大脑中动脉闭塞后暴露于慢性轻度应激。根据对蔗糖偏好和强迫游泳试验成绩的变化来评估卒中后抑郁的发生。雌激素治疗显著改善了这些神经症状，表明雌激素治疗中风后抑郁是有效的。在雌激素治疗两周的大鼠海马区，脑源性神经营养因子(BDNF)的表达增加，这表明BDNF的表达可能是雌激素治疗后卒中后抑郁改善的重要因素。
The present study investigated the effect of exogenous estrogen on post-stroke depression. Rats were exposed to chronic mild stress following middle cerebral artery occlusion. The occurrence of post-stroke depression was evaluated according to the changes in preference for sucrose and performance in a forced swimming test. Estrogen therapy significantly improved these neurological symptoms, indicating that estrogen is effective in treating post-stroke depression. Increased brain-derived neurotrophic factor (BDNF) expression was reported in the hippocampus of rats that had been treated with estrogen for two weeks, suggesting that BDNF expression may be an important contributor to the improvement of post-stroke depression that is observed following estrogen therapy.