Subsequent diabetes in mothers delivered of a malformed infant.
Subsequent diabetes in mothers delivered of a malformed infant.
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生下畸形婴儿的母亲随后患上糖尿病。
DOI：
10.1016/s0140-6736(70)92810-2
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发表时间：
1970
期刊：
影响因子：
168.9
通讯作者：
H. Paniagua
中科院分区：
文献类型：
--
作者：
V. Navarrete;C. E. Rojas;C. Alger;H. Paniagua
对349名出生畸形婴儿的妇女和100名年龄和胎次匹配的对照组进行了观察。已知糖尿病患者在畸形后0、12和25年出现的频率较高且不断增加，分别为6.6%、14.8%和34.3%；加上这些通过口服标准糖耐量试验(通过五种不同的标准评估)被确认为糖尿病的患者，糖尿病(已知糖尿病患者和糖耐量异常)的总发病率在畸形后0、12年和25年分别为16.7、40.4和53.1%，比例略有不同，具体取决于所用的方法。对照组中有1例糖尿病患者和0-3例糖耐量异常患者。这些发现表明，母亲的葡萄糖代谢紊乱与先天性畸形之间存在明确的关系，这一点经常被标准的口服葡萄糖耐量测试忽视，并建议对生育畸形婴儿的母亲的糖尿病状态的早期阶段进行研究。
Observations were made in 349 women who had been delivered of a malformed infant and 100 women selected as an age and parity matched control group. A high and increasing frequency of known diabetics was observed at 0, 12, and 25 years after the malformations, with figures of 6·6, 14·8, and 34·3% respectively; adding to these known diabetics those recognised as such by means of the oral standard glucose-tolerance test (evaluated by five different criteria) the total incidence of diabetes (known diabetics and abnormal glucose tolerance) was 16.7, 40.4, and 53.1% at 0, 12, and 25 years after the malformation, the proportion varying somewhat, depending on the method used. In the control group 1 known diabetic and 0-3 abnormal glucose-tolerance tests were noted. These findings show a definitive relation between a maternal glucose metabolic disorder, frequently overlooked by the standard oral glucose-tolerance test, and congenital malformations, and suggest research into the early phases of diabetic state in mothers bearing a malformed infant.