Polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs) and neuropsychological status among older adults in New York
Polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs) and neuropsychological status among older adults in New York
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DOI：
10.1016/j.neuro.2011.10.011
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发表时间：
2012-01-01
期刊：
影响因子：
3.4
通讯作者：
Hwang, Syni-an
中科院分区：
文献类型：
--
作者：
Fitzgerald, Edward F.;Shrestha, Srishti;Hwang, Syni-an
多溴联苯醚（PBDEs）是一种新兴的环境污染物，但对其可能对人类健康造成的影响知之甚少。本研究的目的是评估多氯联苯暴露与老年人神经心理功能之间的关系，以及多氯联苯（PCBs）影响改变的可能性。分析了144名55-74岁男性和女性的血清样本中9种多溴二苯醚和30种多氯联苯同系物的浓度，并评估了34项认知和运动功能、情感状态和嗅觉功能测试。在对相关混杂因素进行调整后，在血清中PBDE同系物浓度总和（Sigma PBDE）与神经心理测试得分之间没有观察到总体关联。然而，多溴二苯醚和多氯联苯在语言学习和记忆的一些测量中发现了统计学上显著的相互作用。在西格玛多氯联苯浓度在或高于467 ppb（脂质基础）中位数的人群中，西格玛多氯联苯浓度在第25至75百分位之间的增加与加州语言学习测试某些子量表的分数下降7%至12%有关。相比之下，在Sigma多氯联苯水平低于中位数的人群中，没有观察到统计学上显著的关联。结果表明，多溴二苯醚和多氯联苯可能相互作用，影响55-74岁人群的言语记忆和学习。这是第一个评估多溴二苯醚对成人的神经心理影响以及与多氯联苯在人体中协同作用的可能性的研究。(C) 2011爱思唯尔公司版权所有。
Polybrominated diphenyl ethers (PBDEs) are emerging environmental contaminants, but little is known about their possible human health effects. The objective of this study is to evaluate the association between exposure to PBDEs and neuropsychological function among older adults and the possibility of effect modification with polychlorinated biphenyls (PCBs). Serum samples were analyzed for concentrations of 9 PBDE and 30 PCB congeners and 34 tests of cognitive and motor function, affective state, and olfactory function were assessed among 144 men and women of 55-74 years of age. After adjustment for relevant confounders, no overall associations were observed between the sum of the PBDE congener concentrations in serum (Sigma PBDE) and scores on the neuropsychological tests. However, statistically significant interactions were found between PBDEs and PCBs for some measures of verbal learning and memory. Among persons with Sigma PCB concentrations at or above the median of 467 ppb (lipid basis), an increase in Sigma PBDE concentrations from the 25th to 75th percentile was associated with decreases between 7% and 12% on scores for certain subscales of the California Verbal Learning Test. In contrast, no statistically significant associations were observed for PBDEs among persons with Sigma PCB levels below the median. The results suggest that PBDEs and PCBs may interact to affect verbal memory and learning among persons 55-74 years old. This is the first study to evaluate the neuropsychological effects of PBDEs in adults and the possibility of synergy with PCBs in humans. (C) 2011 Elsevier Inc. All rights reserved.