The prevalence of mild cognitive impairment and its etiological subtypes in elderly Chinese
The prevalence of mild cognitive impairment and its etiological subtypes in elderly Chinese
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中国老年人轻度认知障碍患病率及其病因亚型
DOI：
10.1016/j.jalz.2013.09.008
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发表时间：
2014-07-01
影响因子：
14
通讯作者：
Dong, Xiumin
中科院分区：
文献类型：
--
作者：
Jia, Jianping;Zhou, Aihong;Dong, Xiumin
背景：中国关于轻度认知障碍（MCI）的流行病学研究有限。方法：采用多阶段整群抽样设计，对10276名65岁及以上社区居民（城市6096人，农村4180人）进行评估并诊断为正常认知、MCI或痴呆。通过影像学进一步将MCI分为前驱阿尔茨海默病引起的MCI（MCI-A）、脑血管疾病引起的MCI（MCI-CVD）、伴有血管危险因素的MCI（MCI-VRF）和其他疾病引起的MCI（MCI-O）。结果：总体MCI、MCI-A、MCI-CVD、MCI-VRF和MCI-O的患病率分别为： 20.8%（95% 置信区间 [CI] = 20.0-21.6%）、6.1%（95% CI = 5.7-6.6%）、3.8%（95% CI = 3.4-4.2%）、4.9%（95% CI = 4.5-5.4%）和 5.9%（95% CI = 5.5-6.4%）分别。农村人口总体MCI患病率较高（23.4% vs 16.8%，P < .001）。结论：中国老年人MCI患病率农村高于城市。血管相关 MCI（MCI-CVD 和 MCI-VRF）最为常见。 (C) 2014 年阿尔茨海默病协会。版权所有。
Background: Epidemiologic studies on mild cognitive impairment (MCI) are limited in China.Methods: Using a multistage cluster sampling design, a total of 10,276 community residents (6096 urban, 4180 rural) aged 65 years or older were evaluated and diagnosed with normal cognition, MCI, or dementia. MCI was further categorized by imaging into MCI caused by prodromal Alzheimer's disease (MCI-A), MCI resulting from cerebrovascular disease (MCI-CVD), MCI with vascular risk factors (MCI-VRF), and MCI caused by other diseases (MCI-O).Results: The prevalences of overall MCI, MCI-A, MCI-CVD, MCI-VRF, and MCI-O were 20.8% (95% confidence interval [CI] = 20.0-21.6%), 6.1% (95% CI = 5.7-6.6%), 3.8% (95% CI = 3.4-4.2%), 4.9% (95% CI = 4.5-5.4%), and 5.9% (95% CI = 5.5-6.4%) respectively. The rural population had a higher prevalence of overall MCI (23.4% vs 16.8%, P < .001).Conclusions: The prevalence of MCI in elderly Chinese is higher in rural than in urban areas. Vascular-related MCI (MCI-CVD and MCI-VRF) was most common. (C) 2014 The Alzheimer's Association. All rights reserved.