Historical changes in pneumococcal serogroup distribution: Implications for the era of pneumococcal conjugate vaccines
Historical changes in pneumococcal serogroup distribution: Implications for the era of pneumococcal conjugate vaccines
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DOI：
10.1086/341896
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发表时间：
2002-09-01
影响因子：
11.8
通讯作者：
Klugman, KP
中科院分区：
文献类型：
--
作者：
Feikin, DR;Klugman, KP
在90种肺炎球菌血清型中，已获许可的肺炎球菌结合疫苗（Prevnar）中的7种血清型目前占美国儿童侵袭性肺炎球菌感染的80%以上。我们的目的是记录和解释上个世纪美国肺炎球菌血清群分布的变化。我们使用线性回归评估了血清群分布的时间趋势。1928年至1998年期间，结合疫苗中7个血清群引起的肺炎球菌感染比例显著增加，在13项成人研究中从15%增加到59%，在19项儿科研究中从53%增加到87%。在成人研究中，由“流行”血清群（1-3和5）引起的感染比例显著下降，从71%降至7%，在儿童研究中从18%降至2%。血清群分布的这些历史趋势可以通过抗生素使用、社会经济条件、人群免疫功能低下状态和血液培养实践的变化来解释。
Of the 90 pneumococcal serotypes, the 7 in the licensed pneumococcal conjugate vaccine (Prevnar) currently account for >80% of invasive pneumococcal infections among children in the United States. Our objective was to document and explain the changes in pneumococcal serogroup distribution in the United States during the last century. We evaluated temporal trends in the serogroup distribution, using linear regression. Between 1928 and 1998, the proportion of pneumococcal infections caused by the 7 serogroups in the conjugate vaccine increased significantly, from 15% to 59%, in 13 adult studies, and from 53% to 87%, in 19 pediatric studies. The proportion of infections caused by the "epidemic" serogroups (1-3 and 5) decreased significantly, from 71% to 7%, in the adult studies, and from 18% to 2%, in the studies of children. These historical trends in serogroup distribution may be explained by changes in antibiotic use, socioeconomic conditions, the immunocompromised status of populations, and blood-culturing practices.