Spatial distribution of lead in human primary teeth as a biomarker of pre- and neonatal lead exposure
Spatial distribution of lead in human primary teeth as a biomarker of pre- and neonatal lead exposure
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DOI：
10.1016/j.scitotenv.2006.07.035
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发表时间：
2006-12-01
影响因子：
9.8
通讯作者：
Chan, Sheena W. Y.
中科院分区：
文献类型：
--
作者：
Arora, Manish;Kennedy, Brendan J.;Chan, Sheena W. Y.
铅仍然是我们环境中最危险的毒素之一。由于铅的毒性作用在早期发育过程中最为突出，因此，重要的是要在产前和新生儿期开发一种合适的铅暴露生物标志物。在本研究中，铅的空间分布的测量在釉质和牙本质的10个人乳牙，使用激光烧蚀电感耦合等离子体质谱。新生儿线，可视化使用共聚焦激光扫描显微镜，被用来划定产前和产后地区的样本牙齿。其中四名参与者出生前和出生后形成的牙釉质和牙本质中的铅水平与出生时和一岁时测量的血铅水平进行了比较。牙本质铅平均水平范围为0.17 +/- 0.02至5.60 +/- 1.79 μ g/g，牙釉质铅平均水平范围为0.04 +/- 0.01至1.47 +/- 0.20 μ g/g。初步研究结果表明，牙本质中铅的空间分布反映了血铅水平。本研究展示了一种方法，其中铅在人类乳牙牙本质中的空间分布可用于获得时间信息的环境铅暴露在前和新生儿时期。(c)2006 Elsevier B. V.保留所有权利。
Lead remains one of the most hazardous toxins in our environment. Because the toxic effects of lead are most prominent during early development, it is important to develop a suitable biomarker for lead exposure during the pre- and neonatal periods. In the present study, the spatial distribution of lead was measured in the enamel and dentine of ten human primary teeth using laser ablation-inductively coupled plasma-mass spectrometry. The neonatal line, visualized using confocal laser scanning microscopy, was used to demarcate the pre- and postnatal regions of the sample teeth. Lead levels in pre- and postnatally formed enamel and dentine were compared to blood-lead levels measured at birth and one year of age for four of these participants. Mean dentine-lead levels ranged from 0.17 +/- 0.02 to 5.60 +/- 1.79 mu g/g, and mean enamel-lead levels ranged from 0.04 +/- 0.01 to 1.47 +/- 0.20 mu g/g. The results of this preliminary study showed that the spatial distribution of lead in dentine reflected the blood-lead levels. The present study demonstrates a methodology where the spatial distribution of lead in the dentine of human primary teeth may be used to obtain temporal information of environmental lead exposure during the pre- and neonatal periods. (c) 2006 Elsevier B.V. All rights reserved.