Design of multifunctional FePt/GO nanocomposites for targeting, dual-modal imaging diagnostic and in situ therapeutic potential theranostic platform
Design of multifunctional FePt/GO nanocomposites for targeting, dual-modal imaging diagnostic and in situ therapeutic potential theranostic platform
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DOI：
10.1039/c4ra11589a
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发表时间：
2014-11
期刊：
影响因子：
3.9
通讯作者：
Xiuwen Zheng;Weihong Chen;P. Cui;Zhiming Wang;Wei Zhang
中科院分区：
文献类型：
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作者：
Xiuwen Zheng;Weihong Chen;P. Cui;Zhiming Wang;Wei Zhang
在本工作中，通过一种简单的多元醇法，在氧化石墨烯(GO)表面组装了高度单分散的化学无序面心立方(FCC)FePT纳米颗粒(NPs)，形成了FePT/GO纳米复合材料。所制备的纳米复合材料与生物相容的6臂聚乙二醇胺聚合物、叶酸和异硫氰酸荧光素(FITC)偶联，在生理溶液中表现出高度的稳定性，靶向输送到叶酸受体阳性的癌细胞，并通过荧光(FITC)和磁共振成像显示细胞摄取的双模式。作为pH敏感剂，fccFept纳米粒子由于在癌细胞内产生高活性氧物种而显示出高细胞毒性。因此，由于其靶向、诊断和治疗功能，FePT/GO纳米复合材料在癌症治疗中具有潜在的治疗应用前景。
In this work, highly monodispersed chemically disordered face centered cubic (fcc) FePt nanoparticles (NPs) were assembled on graphene oxide (GO) surface to form FePt/GO nanocomposites via a simple polyol protocol. Conjugated with the biocompatible 6-arm polyethylene glycol-amine polymer, folic acid and fluorescein isothiocyanate (FITC), the as-prepared nanocomposites exhibit high stability in physiological solutions, targeted delivery to folate receptor-positive cancer cells and dual-modal visualization of cellular uptake by fluorescence (FITC) and magnetic resonance imaging. As pH-sensitive agents, the fccFePt NPs display high cytotoxicity because of the generation of highly reactive oxygen species within cancer cells. Due to their targeting, diagnostic and therapeutic functions, the FePt/GO nanocomposites are therefore promising for potential theranostic applications in cancer treatment.