TRACE-ELEMENTS IN BLOOD AND SEMINAL PLASMA AND THEIR RELATIONSHIP TO SPERM QUALITY
TRACE-ELEMENTS IN BLOOD AND SEMINAL PLASMA AND THEIR RELATIONSHIP TO SPERM QUALITY
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DOI：
10.1016/0890-6238(93)90038-9
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发表时间：
1993-11-01
影响因子：
3.3
通讯作者：
ONG, CN
中科院分区：
文献类型：
--
作者：
XU, B;CHIA, SE;ONG, CN
测定了221名新加坡男性血液和精浆中镉、铅、硒和锌的浓度。微量元素浓度与精子密度、活力、形态和精液量的关系也进行了研究。各元素含量的顺序为Zn > Se > Pb > Cd。除锌外，血液中的浓度一般高于精浆。精浆中锌的平均浓度（ZnSP）约为血液中锌浓度（ZnB）的30倍。精子密度低于2000万/mL的少精子症患者血镉水平与精子密度呈负相关（r =-0.24，P < 0.05），而正常精子症患者血镉水平与精子密度无相关性。精浆镉（CdSP）水平与精液量低有关（r =-0.29，P < 0.05）。这些发现表明，镉可能对男性生殖系统有影响。与此相反，精浆中硒和锌的浓度（SeSP和ZnSP）和精子密度之间的正相关关系，在正常精子的男性，但在少精子症男性。SeSP和ZnSP与精子密度的相关系数分别为0.35（P < 0.05）和0.41（P < 0.01）。血铅（PbB）或精浆铅（PbSP）的浓度似乎与研究的精子参数没有任何相关性。
The concentrations of cadmium, lead, selenium, and zinc in blood and seminal plasma were determined in 221 Singapore men. The relationship of trace element concentration to sperm density, motility, morphology, and semen volume was also investigated. The concentrations of elements were in the following descending order: Zn > Se > Pb > Cd. Except for zinc, the concentrations were generally higher in blood than in seminal plasma. The mean concentration of zinc in seminal plasma (ZnSP) was about 30 times higher than in blood (ZnB). A significant inverse correlation was observed between blood cadmium levels (CdB) and sperm density (r = -0.24, P < 0.05) in oligozoospermic men (sperm density below 20 million/mL) but not in normospermic men. Cadmium in seminal plasma (CdSP) was also associated with low semen volume (r = -0.29, P < 0.05). These findings suggest that cadmium may have an effect on the male reproductive system. In contrast, positive correlations were observed between concentrations of selenium and zinc in seminal plasma (SeSP and ZnSP) and sperm density in normospermic men but not in oligozoospermic men. The correlation coefficients with sperm density for SeSP and ZnSP were 0.35 (P < 0.05) and 0.41 (P < 0.01), respectively. The concentrations of lead in blood (PbB) or seminal plasma (PbSP) did not appear to have any correlation with the sperm parameters studied.