HLA and mate selection: No evidence in South Amerindians
HLA and mate selection: No evidence in South Amerindians
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DOI：
10.1086/515519
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发表时间：
1997-09-01
影响因子：
9.8
通讯作者：
Black, FL
中科院分区：
文献类型：
--
作者：
Hedrick, PW;Black, FL
有报道称，在小鼠和人类中，存在对不同主要组织相容性复合体（MHC）基因型个体的非随机交配（负分类交配）或偏好。我们研究了来自11个南美印第安部落的194对伴侣的HLA-A和HLA-B基因型的关联，无论是单个基因座还是双基因座。在10个部落中，抽样夫妇的比例平均为有后代的总配对的50%。在几乎所有的情况下，hla共享比例非常接近随机交配的预期，这表明MHC的强烈负分类交配不存在于这些南美印第安人身上。
There have been reports of nonrandom mating (negative-assortative mating) or preference for individuals of different major histocompatibility complex (MHC) genotypes in both mice and humans. We have examined the association of HLA-A and HLA-B genotypes, both for each locus by itself and for two-locus genotypes, in mates of 194 couples from 11 South Amerindian tribes. The proportion of couples sampled averaged >50% of the total matings with progeny for 10 of the tribes. In nearly all cases, HLA-sharing proportions were very close to those expected from random mating, suggesting strong negative-assortative mating for MHC is not present in these South Amerindians.