Insights into the role of long non-coding RNAs in DNA methylation mediated transcriptional regulation.
Insights into the role of long non-coding RNAs in DNA methylation mediated transcriptional regulation.
复制标题
深入了解长链非编码 RNA 在 DNA 甲基化介导的转录调控中的作用
DOI：
10.3389/fmolb.2022.1067406
复制
发表时间：
2022
影响因子：
5
通讯作者：
中科院分区：
文献类型：
--
作者：
DNA甲基化是调控基因表达的最重要的表观遗传机制之一，异常的DNA甲基化模式与人类恶性肿瘤密切相关。长链非编码rna （Long non-coding rna, lncRNAs）已被发现在表观遗传水平上对基因表达具有重要的调控作用。新出现的证据表明lncrna和DNA甲基化之间存在复杂的调控作用。lncRNA的转录一方面受启动子甲基化控制，类似于蛋白质编码基因，另一方面lncRNA可以与参与DNA甲基化的酶相互作用，影响下游基因的甲基化模式，从而调控下游基因的表达。此外，环状RNA （circRNAs）作为一类重要的非编码RNA也被发现参与了这个复杂的调控网络。本文就lncRNA、circRNA与DNA甲基化之间的这种串扰及其在包括癌症在内的复杂疾病中的潜在功能的研究进展进行综述。这项工作揭示了基因转录调控的隐藏层，增强了我们对lncRNA在人类癌症中调控功能的详细机制的表观遗传学理解。
DNA methylation is one of the most important epigenetic mechanisms that governing regulation of gene expression, aberrant DNA methylation patterns are strongly associated with human malignancies. Long non-coding RNAs (lncRNAs) have being discovered as a significant regulator on gene expression at the epigenetic level. Emerging evidences have indicated the intricate regulatory effects between lncRNAs and DNA methylation. On one hand, transcription of lncRNAs are controlled by the promoter methylation, which is similar to protein coding genes, on the other hand, lncRNA could interact with enzymes involved in DNA methylation to affect the methylation pattern of downstream genes, thus regulating their expression. In addition, circular RNAs (circRNAs) being an important class of noncoding RNA are also found to participate in this complex regulatory network. In this review, we summarize recent research progress on this crosstalk between lncRNA, circRNA, and DNA methylation as well as their potential functions in complex diseases including cancer. This work reveals a hidden layer for gene transcriptional regulation and enhances our understanding for epigenetics regarding detailed mechanisms on lncRNA regulatory function in human cancers.
登录
查看更多内容
影响因子：
11.1
作者：
Cheng D;Deng J;Zhang B;He X;Meng Z;Li G;Ye H;Zheng S;Wei L;Deng X;Chen R;Zhou J
通讯作者：
Zhou J
影响因子：
9
作者：
Bao X;Ren T;Huang Y;Sun K;Wang S;Liu K;Zheng B;Guo W
通讯作者：
Guo W
影响因子：
--
作者：
Zhang C;Wang X;Li X;Zhao N;Wang Y;Han X;Ci C;Zhang J;Li M;Zhang Y
通讯作者：
Zhang Y
影响因子：
2.4
作者：
Byun HJ;Yoon JH;Lee SK
通讯作者：
Lee SK
影响因子：
64.8
作者：
通讯作者：
--