The evolution of plastic recombination
The evolution of plastic recombination
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DOI：
10.1534/genetics.105.041301
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发表时间：
2005-10-01
期刊：
影响因子：
3.3
通讯作者：
Otto, SP
中科院分区：
文献类型：
--
作者：
Agrawal, AF;Hadany, L;Otto, SP
经验数据表明，重组率可能会随着压力的变化而变化。为了研究塑性复合的演变，我们开发了一个改性剂模型，使用与研究常规（非塑性）改性剂相同的理论框架，从而允许直接比较。我们研究了在单倍体和二倍体系统中塑料重组的进化。在单倍体中，塑性修饰子通过与选择性偏爱的等位基因形成结合而传播。相对于非塑性效应，修饰剂的塑性效应更强，对选择机制的具体情况（如上位性）不太敏感。相比之下，在二倍体中，可塑性重组的进化受到更大的限制。对可塑性的选择需要能够检测DNA损伤或顺反效应，这可能通过母体对适应性的影响而发生。
Empirical data suggest that recombination rates may change in response to stress. To study the evolution of plastic recombination, we develop a modifier model using the same theoretical framework used to study conventional (nonplastic) modifiers, thus allowing direct comparison. We examine the evolution of plastic recombination in both haploid and diploid systems. In haploids, a plastic modifier spreads by forming associations with selectively favored alleles. Relative to nonplastic effects, selection On the plastic effects of a modifier is both much stronger and less sensitive to the specifics of the selection regime (e.g., epistasis). In contrast, the evolution of plastic recombination in diploids is much more restricted. Selection on plasticity requires the ability to detect DNA damage or cis-trans effects as may Occur trough maternal effects on fitness.