Dendritic cells: nature and classification.
Dendritic cells: nature and classification.
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DOI：
10.2332/allergolint.r-06-139
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发表时间：
2007-09-01
期刊：
影响因子：
--
通讯作者：
Fujita, Shigeharu
中科院分区：
文献类型：
--
作者：
Sato, Katsuaki;Fujita, Shigeharu
树突状细胞（Dendritic cells，DC）是一种抗原呈递细胞（antigen presenting cells，APC），具有刺激初始T细胞（naive T cells，naive T cells）和启动初次免疫应答的独特能力。最近的研究表明，DC还在诱导中枢和外周免疫耐受，调节T细胞免疫应答的类型，以及在针对微生物的天然免疫中作为哨兵发挥关键作用。DC在免疫调节中的多样性功能依赖于DC亚群的异质性及其功能可塑性。在这里，我们回顾了最近的进展，我们的理解的性质和分类的DC。
Dendritic cells (DCs) are antigen (Ag)-presenting cells (APCs) characterized by a unique capacity to stimulate naive T cells and initiate primary immune responses. Recent studies suggest that DCs also play critical roles in the induction of central and peripheral immunological tolerance, regulate the types of T cell immune responses, and function as sentinels in innate immunity against microbes. The diverse functions of DCs in immune regulation depend on the heterogeneity of DC subsets and their functional plasticity. Here we review recent progress in our understanding of the nature and classification of DCs.